STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1025 aa)    
Predicted Functional Partners:
FANCD2
Uncharacterized protein.
    
 0.996
FANCM
FA complementation group M.
   
 0.985
MLH1
MutL homolog 1.
   
 0.983
PMS2
PMS1 homolog 2, mismatch repair system component.
   
 0.967
FANCI
FA complementation group I.
   
 0.918
ENSOCUP00000040692
Uncharacterized protein.
    
 0.848
POLK
UmuC domain-containing protein.
   
  
 0.838
ERCC1
Uncharacterized protein.
     
 0.803
EME1
Essential meiotic structure-specific endonuclease 1.
   
 
 0.799
ENSOCUP00000033462
Uncharacterized protein.
    
 0.794
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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