Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
WDFY1Uncharacterized protein. (410 aa)    
Predicted Functional Partners:
AP1S3
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
 
   
 0.764
NUDCD1
NudC domain containing 1.
    
   0.745
AP1S2
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
 
   
 0.738
WDFY4
WDFY family member 4.
      
 0.627
AK9
Uncharacterized protein.
   
 0.619
GPR37
G protein-coupled receptor 37.
    
  0.613
VAMP8
Vesicle associated membrane protein 8.
    
  0.588
G1SQG4_RABIT
Uncharacterized protein.
   
  0.556
PPP4C
Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]
   
 0.541
TBC1D31
TBC1 domain family member 31.
     
 0.537
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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