Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ALPLAlkaline phosphatase. (558 aa)    
Predicted Functional Partners:
BGLAP
Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
      
 0.875
TPK1
Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family.
     
  0.851
PTS
6-pyruvoyl tetrahydrobiopterin synthase.
     
  0.851
NTPCR
Nucleoside-triphosphatase, cancer-related.
     
  0.851
RUNX2
RUNX family transcription factor 2.
    
 
 0.838
IBSP
Integrin binding sialoprotein.
      
 0.787
SPP1
Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family.
    
 
 0.779
ACP1
LMWPc domain-containing protein.
    
 0.773
LOC100356234
LMWPc domain-containing protein.
    
 0.773
NANOG
Homeobox domain-containing protein.
      
 0.769
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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