STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYCARDPYD and CARD domain containing. (196 aa)    
Predicted Functional Partners:
CASP1
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.999
NLRP3
NLR family pyrin domain containing 3.
     
 0.999
LOC100358658
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.999
IL1B
Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.
   
 
 0.992
IL18
Uncharacterized protein.
   
 
 0.990
NLRP12
NLR family pyrin domain containing 12.
   
 0.986
CASP8
DED domain-containing protein.
    
 0.950
MEFV
MEFV innate immuity regulator, pyrin.
    
0.905
CASP4
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.893
GSDMD
Gasdermin D.
      
 0.829
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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