PTPN11 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	FRS2	ENSOCUP00000009041	ENSOCUP00000014769	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor substrate 2.	0.609
EGFR	GAB1	ENSOCUP00000009041	ENSOCUP00000002840	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.991
EGFR	GAB2	ENSOCUP00000009041	ENSOCUP00000015611	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 2.	0.967
EGFR	GRB2	ENSOCUP00000009041	ENSOCUP00000042433	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.997
EGFR	JAK2	ENSOCUP00000009041	ENSOCUP00000014491	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.975
EGFR	PDGFRB	ENSOCUP00000009041	ENSOCUP00000001483	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.968
EGFR	PECAM1	ENSOCUP00000009041	ENSOCUP00000013077	Receptor protein-tyrosine kinase.	Platelet and endothelial cell adhesion molecule 1.	0.467
EGFR	PIK3R1	ENSOCUP00000009041	ENSOCUP00000004433	Receptor protein-tyrosine kinase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.994
EGFR	PTPN11	ENSOCUP00000009041	ENSOCUP00000003911	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.995
EGFR	SOS1	ENSOCUP00000009041	ENSOCUP00000019739	Receptor protein-tyrosine kinase.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.995
FRS2	EGFR	ENSOCUP00000014769	ENSOCUP00000009041	Fibroblast growth factor receptor substrate 2.	Receptor protein-tyrosine kinase.	0.609
FRS2	GAB1	ENSOCUP00000014769	ENSOCUP00000002840	Fibroblast growth factor receptor substrate 2.	GRB2 associated binding protein 1.	0.851
FRS2	GRB2	ENSOCUP00000014769	ENSOCUP00000042433	Fibroblast growth factor receptor substrate 2.	Growth factor receptor bound protein 2.	0.996
FRS2	PDGFRB	ENSOCUP00000014769	ENSOCUP00000001483	Fibroblast growth factor receptor substrate 2.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.402
FRS2	PIK3R1	ENSOCUP00000014769	ENSOCUP00000004433	Fibroblast growth factor receptor substrate 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.591
FRS2	PTPN11	ENSOCUP00000014769	ENSOCUP00000003911	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.990
FRS2	SOS1	ENSOCUP00000014769	ENSOCUP00000019739	Fibroblast growth factor receptor substrate 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.935
GAB1	EGFR	ENSOCUP00000002840	ENSOCUP00000009041	GRB2 associated binding protein 1.	Receptor protein-tyrosine kinase.	0.991
GAB1	FRS2	ENSOCUP00000002840	ENSOCUP00000014769	GRB2 associated binding protein 1.	Fibroblast growth factor receptor substrate 2.	0.851
GAB1	GAB2	ENSOCUP00000002840	ENSOCUP00000015611	GRB2 associated binding protein 1.	GRB2 associated binding protein 2.	0.856