| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTXN2 | FBXO43 | ENSOCUP00000019597 | ENSOCUP00000007575 | Cortexin 2. | F-box protein 43. | 0.795 |
| CTXN2 | KCNS2 | ENSOCUP00000019597 | ENSOCUP00000003914 | Cortexin 2. | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | 0.805 |
| FAU | G1U1Y5_RABIT | ENSOCUP00000042864 | ENSOCUP00000023377 | Ubiquitin-like domain-containing protein. | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | 0.943 |
| FAU | KCNB1 | ENSOCUP00000042864 | ENSOCUP00000017212 | Ubiquitin-like domain-containing protein. | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] | 0.628 |
| FAU | KCNB2 | ENSOCUP00000042864 | ENSOCUP00000002420 | Ubiquitin-like domain-containing protein. | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | 0.628 |
| FAU | KCNS1 | ENSOCUP00000042864 | ENSOCUP00000021157 | Ubiquitin-like domain-containing protein. | Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. | 0.628 |
| FAU | KCNS2 | ENSOCUP00000042864 | ENSOCUP00000003914 | Ubiquitin-like domain-containing protein. | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | 0.628 |
| FAU | KCNS3 | ENSOCUP00000042864 | ENSOCUP00000006367 | Ubiquitin-like domain-containing protein. | Potassium voltage-gated channel subfamily S member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. [...] | 0.628 |
| FBXO43 | CTXN2 | ENSOCUP00000007575 | ENSOCUP00000019597 | F-box protein 43. | Cortexin 2. | 0.795 |
| FBXO43 | KCNS2 | ENSOCUP00000007575 | ENSOCUP00000003914 | F-box protein 43. | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | 0.780 |
| G1U1Y5_RABIT | FAU | ENSOCUP00000023377 | ENSOCUP00000042864 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Ubiquitin-like domain-containing protein. | 0.943 |
| G1U1Y5_RABIT | KCNB1 | ENSOCUP00000023377 | ENSOCUP00000017212 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] | 0.628 |
| G1U1Y5_RABIT | KCNB2 | ENSOCUP00000023377 | ENSOCUP00000002420 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | 0.628 |
| G1U1Y5_RABIT | KCNS1 | ENSOCUP00000023377 | ENSOCUP00000021157 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. | 0.628 |
| G1U1Y5_RABIT | KCNS2 | ENSOCUP00000023377 | ENSOCUP00000003914 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | 0.628 |
| G1U1Y5_RABIT | KCNS3 | ENSOCUP00000023377 | ENSOCUP00000006367 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Potassium voltage-gated channel subfamily S member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. [...] | 0.628 |
| KCNAB1 | KCNB1 | ENSOCUP00000044774 | ENSOCUP00000017212 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...] | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] | 0.791 |
| KCNAB1 | KCNB2 | ENSOCUP00000044774 | ENSOCUP00000002420 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...] | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] | 0.638 |
| KCNAB1 | KCNS1 | ENSOCUP00000044774 | ENSOCUP00000021157 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...] | Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. | 0.586 |
| KCNAB1 | KCNS2 | ENSOCUP00000044774 | ENSOCUP00000003914 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...] | Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. | 0.647 |
