STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPS6KB1Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (490 aa)    
Predicted Functional Partners:
MTOR
Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.
    
 0.994
ENSOCUP00000043082
Uncharacterized protein.
    
 0.965
RICTOR
RPTOR independent companion of MTOR complex 2.
    
 0.964
TSC2
TSC complex subunit 2.
   
 0.963
RPS6
40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 0.945
PDPK1
3-phosphoinositide dependent protein kinase 1; Belongs to the protein kinase superfamily.
  
 
0.938
G1TM55_RABIT
40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.
    
 0.926
MLST8
MTOR associated protein, LST8 homolog.
   
 0.925
RHEB
Ras homolog, mTORC1 binding.
   
 0.923
EIF4B
Eukaryotic translation initiation factor 4B.
   
 0.916
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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