RPS6KB1 protein (Oryctolagus cuniculus) - STRING interaction network

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RPS6KB1

Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (490 aa)

Predicted Functional Partners:

MTOR

0.996

ENSOCUP00000043082

0.990

MLST8

0.982

DEPTOR

0.976

EIF4B

0.974

PDPK1

0.973

RPS6

0.971

TSC2

0.970

EEF2K

0.964

G1TM55_RABIT

0.956

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEPTOR	ENSOCUP00000043082	ENSOCUP00000044330	ENSOCUP00000043082	DEP domain containing MTOR interacting protein.	Uncharacterized protein.	0.992
DEPTOR	MLST8	ENSOCUP00000044330	ENSOCUP00000039995	DEP domain containing MTOR interacting protein.	MTOR associated protein, LST8 homolog.	0.996
DEPTOR	MTOR	ENSOCUP00000044330	ENSOCUP00000011253	DEP domain containing MTOR interacting protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.992
DEPTOR	RPS6	ENSOCUP00000044330	ENSOCUP00000002892	DEP domain containing MTOR interacting protein.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.518
DEPTOR	RPS6KB1	ENSOCUP00000044330	ENSOCUP00000003969	DEP domain containing MTOR interacting protein.	Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...]	0.976
DEPTOR	TSC2	ENSOCUP00000044330	ENSOCUP00000037655	DEP domain containing MTOR interacting protein.	TSC complex subunit 2.	0.813
EEF2K	EIF4B	ENSOCUP00000006973	ENSOCUP00000011602	Eukaryotic elongation factor 2 kinase.	Eukaryotic translation initiation factor 4B.	0.701
EEF2K	G1TM55_RABIT	ENSOCUP00000006973	ENSOCUP00000018062	Eukaryotic elongation factor 2 kinase.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.582
EEF2K	MTOR	ENSOCUP00000006973	ENSOCUP00000011253	Eukaryotic elongation factor 2 kinase.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.574
EEF2K	RPS6	ENSOCUP00000006973	ENSOCUP00000002892	Eukaryotic elongation factor 2 kinase.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.660
EEF2K	RPS6KB1	ENSOCUP00000006973	ENSOCUP00000003969	Eukaryotic elongation factor 2 kinase.	Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...]	0.964
EEF2K	TSC2	ENSOCUP00000006973	ENSOCUP00000037655	Eukaryotic elongation factor 2 kinase.	TSC complex subunit 2.	0.409
EIF4B	EEF2K	ENSOCUP00000011602	ENSOCUP00000006973	Eukaryotic translation initiation factor 4B.	Eukaryotic elongation factor 2 kinase.	0.701
EIF4B	ENSOCUP00000043082	ENSOCUP00000011602	ENSOCUP00000043082	Eukaryotic translation initiation factor 4B.	Uncharacterized protein.	0.565
EIF4B	G1TM55_RABIT	ENSOCUP00000011602	ENSOCUP00000018062	Eukaryotic translation initiation factor 4B.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.900
EIF4B	MLST8	ENSOCUP00000011602	ENSOCUP00000039995	Eukaryotic translation initiation factor 4B.	MTOR associated protein, LST8 homolog.	0.463
EIF4B	MTOR	ENSOCUP00000011602	ENSOCUP00000011253	Eukaryotic translation initiation factor 4B.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.697
EIF4B	RPS6	ENSOCUP00000011602	ENSOCUP00000002892	Eukaryotic translation initiation factor 4B.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.918
EIF4B	RPS6KB1	ENSOCUP00000011602	ENSOCUP00000003969	Eukaryotic translation initiation factor 4B.	Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...]	0.974
EIF4B	TSC2	ENSOCUP00000011602	ENSOCUP00000037655	Eukaryotic translation initiation factor 4B.	TSC complex subunit 2.	0.547

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