SHFL protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SHFL

Shiftless antiviral inhibitor of ribosomal frameshifting. (293 aa)

Predicted Functional Partners:

CLSTN2

0.491

RTP4

0.490

SSBP3

0.486

RASGRP3

0.461

KANSL2

0.457

IFI35

0.446

MCRS1

0.439

FBXO15

0.436

MET

0.405

MST1R

0.405

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSTN2	SHFL	ENSOCUP00000028244	ENSOCUP00000004082	Calsyntenin 2.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.491
FBXO15	SHFL	ENSOCUP00000010010	ENSOCUP00000004082	F-box domain-containing protein.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.436
IFI35	RTP4	ENSOCUP00000003358	ENSOCUP00000006643	Uncharacterized protein.	zf-3CxxC domain-containing protein.	0.788
IFI35	SHFL	ENSOCUP00000003358	ENSOCUP00000004082	Uncharacterized protein.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.446
KANSL2	MCRS1	ENSOCUP00000044614	ENSOCUP00000014462	KAT8 regulatory NSL complex subunit 2.	Microspherule protein 1.	0.997
KANSL2	SHFL	ENSOCUP00000044614	ENSOCUP00000004082	KAT8 regulatory NSL complex subunit 2.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.457
MCRS1	KANSL2	ENSOCUP00000014462	ENSOCUP00000044614	Microspherule protein 1.	KAT8 regulatory NSL complex subunit 2.	0.997
MCRS1	SHFL	ENSOCUP00000014462	ENSOCUP00000004082	Microspherule protein 1.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.439
MET	MST1R	ENSOCUP00000003111	ENSOCUP00000008078	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Macrophage stimulating 1 receptor.	0.634
MET	RASGRP3	ENSOCUP00000003111	ENSOCUP00000026427	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	RAS guanyl releasing protein 3.	0.487
MET	SHFL	ENSOCUP00000003111	ENSOCUP00000004082	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.405
MST1R	MET	ENSOCUP00000008078	ENSOCUP00000003111	Macrophage stimulating 1 receptor.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.634
MST1R	RASGRP3	ENSOCUP00000008078	ENSOCUP00000026427	Macrophage stimulating 1 receptor.	RAS guanyl releasing protein 3.	0.487
MST1R	SHFL	ENSOCUP00000008078	ENSOCUP00000004082	Macrophage stimulating 1 receptor.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.405
RASGRP3	MET	ENSOCUP00000026427	ENSOCUP00000003111	RAS guanyl releasing protein 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.487
RASGRP3	MST1R	ENSOCUP00000026427	ENSOCUP00000008078	RAS guanyl releasing protein 3.	Macrophage stimulating 1 receptor.	0.487
RASGRP3	SHFL	ENSOCUP00000026427	ENSOCUP00000004082	RAS guanyl releasing protein 3.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.461
RTP4	IFI35	ENSOCUP00000006643	ENSOCUP00000003358	zf-3CxxC domain-containing protein.	Uncharacterized protein.	0.788
RTP4	SHFL	ENSOCUP00000006643	ENSOCUP00000004082	zf-3CxxC domain-containing protein.	Shiftless antiviral inhibitor of ribosomal frameshifting.	0.490
RTP4	SSBP3	ENSOCUP00000006643	ENSOCUP00000038179	zf-3CxxC domain-containing protein.	Single stranded DNA binding protein 3.	0.443