Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PICK1Protein interacting with PRKCA 1. (333 aa)    
Predicted Functional Partners:
GRIA2
Glutamate ionotropic receptor AMPA type subunit 2.
    
 0.983
TSPAN7
Tetraspanin.
    
 0.943
GRIA1
Glutamate ionotropic receptor AMPA type subunit 1.
    
 0.939
GRIP1
Glutamate receptor interacting protein 1.
    
 0.938
GRIA3
Glutamate ionotropic receptor AMPA type subunit 3.
    
 0.920
NHSL2
NHS like 2.
    
   0.917
GRIA4
Glutamate ionotropic receptor AMPA type subunit 4.
    
 0.891
PRKCA
Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...]
    
 0.885
GRIP2
Glutamate receptor interacting protein 2.
   
 0.859
SPATA16
Spermatogenesis associated 16.
      
 0.825
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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