ROCK1 protein (Oryctolagus cuniculus) - STRING interaction network

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Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	PTEN	ENSOCUP00000036614	ENSOCUP00000007574	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.801
CASP3	RHOA	ENSOCUP00000036614	ENSOCUP00000011466	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Ras homolog family member A.	0.676
CASP3	ROCK1	ENSOCUP00000036614	ENSOCUP00000034408	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...]	0.963
CASP3	ROCK2	ENSOCUP00000036614	ENSOCUP00000022038	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.708
LIMK2	RHOA	ENSOCUP00000027956	ENSOCUP00000011466	LIM domain kinase 2.	Ras homolog family member A.	0.689
LIMK2	RHOB	ENSOCUP00000027956	ENSOCUP00000037384	LIM domain kinase 2.	Ras homolog family member B.	0.458
LIMK2	ROCK1	ENSOCUP00000027956	ENSOCUP00000034408	LIM domain kinase 2.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...]	0.955
LIMK2	ROCK2	ENSOCUP00000027956	ENSOCUP00000022038	LIM domain kinase 2.	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.954
MYL2	PPP1R12A	ENSOCUP00000028408	ENSOCUP00000049951	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	Protein phosphatase 1 regulatory subunit.	0.895
MYL2	PPP1R12B	ENSOCUP00000028408	ENSOCUP00000034015	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	Protein phosphatase 1 regulatory subunit.	0.876
MYL2	RHOA	ENSOCUP00000028408	ENSOCUP00000011466	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	Ras homolog family member A.	0.799
MYL2	RHOB	ENSOCUP00000028408	ENSOCUP00000037384	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	Ras homolog family member B.	0.411
MYL2	ROCK1	ENSOCUP00000028408	ENSOCUP00000034408	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...]	0.957
MYL2	ROCK2	ENSOCUP00000028408	ENSOCUP00000022038	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.949
PPP1R12A	MYL2	ENSOCUP00000049951	ENSOCUP00000028408	Protein phosphatase 1 regulatory subunit.	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...]	0.895
PPP1R12A	PPP1R12B	ENSOCUP00000049951	ENSOCUP00000034015	Protein phosphatase 1 regulatory subunit.	Protein phosphatase 1 regulatory subunit.	0.877
PPP1R12A	RHOA	ENSOCUP00000049951	ENSOCUP00000011466	Protein phosphatase 1 regulatory subunit.	Ras homolog family member A.	0.813
PPP1R12A	RHOB	ENSOCUP00000049951	ENSOCUP00000037384	Protein phosphatase 1 regulatory subunit.	Ras homolog family member B.	0.486
PPP1R12A	RND3	ENSOCUP00000049951	ENSOCUP00000001502	Protein phosphatase 1 regulatory subunit.	Rho family GTPase 3.	0.454
PPP1R12A	ROCK1	ENSOCUP00000049951	ENSOCUP00000034408	Protein phosphatase 1 regulatory subunit.	Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...]	0.986