PDX1 protein (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

PDX1

Pancreatic and duodenal homeobox 1. (336 aa)

Predicted Functional Partners:

PRKACB

0.916

INS

0.875

SPOP

0.840

GCK

0.828

FOXA2

0.790

PAX4

0.774

GCG

0.769

SST

0.719

FOXO1

0.717

PPY

0.708

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXA2	FOXO1	ENSOCUP00000006365	ENSOCUP00000012389	Forkhead box A2.	Fork-head domain-containing protein.	0.581
FOXA2	GCG	ENSOCUP00000006365	ENSOCUP00000019727	Forkhead box A2.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.608
FOXA2	INS	ENSOCUP00000006365	ENSOCUP00000020463	Forkhead box A2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.672
FOXA2	PAX4	ENSOCUP00000006365	ENSOCUP00000001386	Forkhead box A2.	Paired box 4.	0.692
FOXA2	PDX1	ENSOCUP00000006365	ENSOCUP00000004229	Forkhead box A2.	Pancreatic and duodenal homeobox 1.	0.790
FOXA2	SST	ENSOCUP00000006365	ENSOCUP00000006540	Forkhead box A2.	Somatostatin.	0.461
FOXO1	FOXA2	ENSOCUP00000012389	ENSOCUP00000006365	Fork-head domain-containing protein.	Forkhead box A2.	0.581
FOXO1	GCG	ENSOCUP00000012389	ENSOCUP00000019727	Fork-head domain-containing protein.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.709
FOXO1	GCK	ENSOCUP00000012389	ENSOCUP00000032410	Fork-head domain-containing protein.	Phosphotransferase.	0.609
FOXO1	INS	ENSOCUP00000012389	ENSOCUP00000020463	Fork-head domain-containing protein.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.878
FOXO1	PAX4	ENSOCUP00000012389	ENSOCUP00000001386	Fork-head domain-containing protein.	Paired box 4.	0.447
FOXO1	PDX1	ENSOCUP00000012389	ENSOCUP00000004229	Fork-head domain-containing protein.	Pancreatic and duodenal homeobox 1.	0.717
FOXO1	PRKACB	ENSOCUP00000012389	ENSOCUP00000043583	Fork-head domain-containing protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.954
GCG	FOXA2	ENSOCUP00000019727	ENSOCUP00000006365	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Forkhead box A2.	0.608
GCG	FOXO1	ENSOCUP00000019727	ENSOCUP00000012389	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Fork-head domain-containing protein.	0.709
GCG	GCK	ENSOCUP00000019727	ENSOCUP00000032410	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Phosphotransferase.	0.776
GCG	INS	ENSOCUP00000019727	ENSOCUP00000020463	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.958
GCG	PAX4	ENSOCUP00000019727	ENSOCUP00000001386	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Paired box 4.	0.838
GCG	PDX1	ENSOCUP00000019727	ENSOCUP00000004229	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Pancreatic and duodenal homeobox 1.	0.769
GCG	PPY	ENSOCUP00000019727	ENSOCUP00000025326	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family.	0.916