Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)    
Predicted Functional Partners:
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
   
 0.999
LOC100345250
Uncharacterized protein.
   
 0.999
EGFR
Receptor protein-tyrosine kinase.
    
 0.986
PIK3R5
Phosphoinositide-3-kinase regulatory subunit 5.
   
 0.985
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
  
0.984
CBL
Cbl proto-oncogene.
    
 0.971
PTEN
Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.
   
 0.969
MTOR
Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.
    
0.962
PIK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
  
  
0.961
CDC42-2
Uncharacterized protein.
   
 0.960
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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