SFXN4 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SFXN4

Sideroflexin 4. (325 aa)

Predicted Functional Partners:

PRADC1

0.743

PRSS37

0.661

CCDC18

0.657

AGK

0.596

TIMM22

0.579

NANOS2

0.569

DNAJC19

0.558

TIMM29

0.547

UACA

0.533

TIMM50

0.522

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGK	SFXN4	ENSOCUP00000015071	ENSOCUP00000004335	Acylglycerol kinase.	Sideroflexin 4.	0.596
AGK	TIMM22	ENSOCUP00000015071	ENSOCUP00000006939	Acylglycerol kinase.	Translocase of inner mitochondrial membrane 22.	0.912
AGK	TIMM29	ENSOCUP00000015071	ENSOCUP00000002933	Acylglycerol kinase.	Translocase of inner mitochondrial membrane 29.	0.963
AGK	TIMM50	ENSOCUP00000015071	ENSOCUP00000001869	Acylglycerol kinase.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.530
CCDC18	PRADC1	ENSOCUP00000010709	ENSOCUP00000002097	Coiled-coil domain containing 18.	Protease associated domain containing 1.	0.714
CCDC18	PRSS37	ENSOCUP00000010709	ENSOCUP00000005311	Coiled-coil domain containing 18.	Serine protease 37.	0.670
CCDC18	SFXN4	ENSOCUP00000010709	ENSOCUP00000004335	Coiled-coil domain containing 18.	Sideroflexin 4.	0.657
CCDC18	UACA	ENSOCUP00000010709	ENSOCUP00000039237	Coiled-coil domain containing 18.	Uveal autoantigen with coiled-coil domains and ankyrin repeats.	0.599
DNAJC19	SFXN4	ENSOCUP00000012070	ENSOCUP00000004335	DnaJ heat shock protein family (Hsp40) member C19.	Sideroflexin 4.	0.558
DNAJC19	TIMM22	ENSOCUP00000012070	ENSOCUP00000006939	DnaJ heat shock protein family (Hsp40) member C19.	Translocase of inner mitochondrial membrane 22.	0.628
DNAJC19	TIMM29	ENSOCUP00000012070	ENSOCUP00000002933	DnaJ heat shock protein family (Hsp40) member C19.	Translocase of inner mitochondrial membrane 29.	0.408
DNAJC19	TIMM50	ENSOCUP00000012070	ENSOCUP00000001869	DnaJ heat shock protein family (Hsp40) member C19.	Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.	0.759
NANOS2	SFXN4	ENSOCUP00000020040	ENSOCUP00000004335	Nanos C2HC-type zinc finger 2; Belongs to the nanos family.	Sideroflexin 4.	0.569
PRADC1	CCDC18	ENSOCUP00000002097	ENSOCUP00000010709	Protease associated domain containing 1.	Coiled-coil domain containing 18.	0.714
PRADC1	PRSS37	ENSOCUP00000002097	ENSOCUP00000005311	Protease associated domain containing 1.	Serine protease 37.	0.731
PRADC1	SFXN4	ENSOCUP00000002097	ENSOCUP00000004335	Protease associated domain containing 1.	Sideroflexin 4.	0.743
PRADC1	UACA	ENSOCUP00000002097	ENSOCUP00000039237	Protease associated domain containing 1.	Uveal autoantigen with coiled-coil domains and ankyrin repeats.	0.700
PRSS37	CCDC18	ENSOCUP00000005311	ENSOCUP00000010709	Serine protease 37.	Coiled-coil domain containing 18.	0.670
PRSS37	PRADC1	ENSOCUP00000005311	ENSOCUP00000002097	Serine protease 37.	Protease associated domain containing 1.	0.731
PRSS37	SFXN4	ENSOCUP00000005311	ENSOCUP00000004335	Serine protease 37.	Sideroflexin 4.	0.661

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.803

expected number of edges:

14

PPI enrichment p-value:

1.95e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007601

Visual perception

5 of 105

1.9

2.16

2.51e-05

GO:0051606

Detection of stimulus

5 of 202

1.62

1.69

0.00010

GO:0007602

Phototransduction

3 of 28

2.25

1.69

0.00063

GO:0007603

Phototransduction, visible light

2 of 4

2.92

1.39

0.0030

GO:0001580

Detection of chemical stimulus involved in sensory perception of bitter taste

2 of 5

2.82

1.33

0.0039

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004703

G protein-coupled receptor kinase activity

3 of 8

2.8

2.28

6.64e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 34

2.39

3.91

1.89e-08

GO:0001750

Photoreceptor outer segment

4 of 49

2.13

2.69

3.57e-06

GO:0001917

Photoreceptor inner segment

3 of 36

2.14

1.97

0.00014

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:25806532

(2015) Transducin duplicates in the zebrafish retina and pineal complex: differential specialisation after the teleost tetraploidisation.

5 of 7

3.08

5.85

1.60e-11

PMID:29321241

(2018) Evolution of the shut-off steps of vertebrate phototransduction.

3 of 5

3.0

3.41e-06

PMID:27296292

(2016) Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity.

3 of 7

2.85

2.89

4.87e-06

PMID:35412676

(2022) Photoreceptor physiology and evolution: cellular and molecular basis of rod and cone phototransduction.

3 of 11

2.66

2.67

1.11e-05

PMID:30257895

(2018) Evolution of the calcium feedback steps of vertebrate phototransduction.

3 of 11

2.66

2.67

1.11e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:27653

Rhodopsin, and GPCR kinase

6 of 11

2.96

6.77

2.08e-13

CL:27402

Mixed, incl. Amine ligand-binding receptors, and GTPase complex

11 of 172

2.03

6.6

2.76e-19

CL:27656

Methylation, and Vision

4 of 5

3.13

4.58

4.24e-09

CL:27492

Sensory perception of bitter taste, and Retinal cGMP phosphodiesterase, gamma subunit

4 of 5

3.13

4.58

4.24e-09

CL:27427

GTPase complex, and Prostanoid receptor

5 of 39

2.33

3.96

1.11e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04744

Phototransduction

10 of 39

2.63

10.84

1.47e-23

map04371

Apelin signaling pathway

3 of 144

1.54

0.98

0.0077

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2514856

The phototransduction cascade

9 of 42

2.55

8.78

4.24e-19

MAP-2514859

Inactivation, recovery and regulation of the phototransduction cascade

8 of 41

2.51

7.57

1.92e-16

MAP-2187338

Visual phototransduction

9 of 118

2.1

6.06

8.18e-16

MAP-9709957

Sensory Perception

10 of 264

1.8

4.65

2.10e-15

MAP-2485179

Activation of the phototransduction cascade

4 of 16

2.62

3.68

1.11e-07

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 10491

0.24

0.23

0.0194

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0001917

Photoreceptor inner segment

4 of 22

2.48

3.05

1.55e-06

GOCC:0005834

Heterotrimeric G-protein complex

3 of 10

2.7

2.42

3.41e-05

GOCC:0001750

Photoreceptor outer segment

2 of 38

1.94

0.76

0.0376

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0488

Methylation

2 of 2

3.22

1.77

0.00064

KW-0723

Serine/threonine-protein kinase

3 of 194

1.41

0.73

0.0270

KW-0807

Transducer

4 of 569

1.07

0.61

0.0270

KW-0547

Nucleotide-binding

5 of 993

0.92

0.54

0.0270

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000239

GPCR kinase

3 of 8

2.8

2.06

0.00017

IPR044926

RGS, subdomain 2

3 of 38

2.12

1.21

0.0052

IPR036305

RGS domain superfamily

3 of 38

2.12

1.21

0.0052

IPR016137

RGS domain

3 of 37

2.13

1.21

0.0052

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 5

2.82

1.17

0.0075

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00315

Regulator of G protein signalling domain

3 of 32

2.19

1.63

0.00078

SM00133

Extension to Ser/Thr-type protein kinases

3 of 54

1.97

1.41

0.0017

SM00275

G protein alpha subunit

2 of 15

2.35

1.06

0.0111

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