RFC4 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RFC4

Replication factor C subunit 4. (364 aa)

Predicted Functional Partners:

RFC3

0.999

RFC5

0.999

RFC2

0.999

PCNA

0.998

RFC1

0.998

RAD17

0.996

ATAD5

0.995

DSCC1

0.993

FEN1

0.976

LIG1

0.972

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	DSCC1	ENSOCUP00000021311	ENSOCUP00000015422	ATPase family AAA domain containing 5.	DNA replication and sister chromatid cohesion 1.	0.914
ATAD5	FEN1	ENSOCUP00000021311	ENSOCUP00000002851	ATPase family AAA domain containing 5.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.940
ATAD5	LIG1	ENSOCUP00000021311	ENSOCUP00000010183	ATPase family AAA domain containing 5.	DNA ligase.	0.796
ATAD5	PCNA	ENSOCUP00000021311	ENSOCUP00000003512	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.972
ATAD5	RAD17	ENSOCUP00000021311	ENSOCUP00000037201	ATPase family AAA domain containing 5.	RAD17 checkpoint clamp loader component.	0.934
ATAD5	RFC1	ENSOCUP00000021311	ENSOCUP00000004099	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.860
ATAD5	RFC2	ENSOCUP00000021311	ENSOCUP00000041420	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.977
ATAD5	RFC3	ENSOCUP00000021311	ENSOCUP00000003142	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.973
ATAD5	RFC4	ENSOCUP00000021311	ENSOCUP00000004340	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.995
ATAD5	RFC5	ENSOCUP00000021311	ENSOCUP00000008939	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.991
DSCC1	ATAD5	ENSOCUP00000015422	ENSOCUP00000021311	DNA replication and sister chromatid cohesion 1.	ATPase family AAA domain containing 5.	0.914
DSCC1	FEN1	ENSOCUP00000015422	ENSOCUP00000002851	DNA replication and sister chromatid cohesion 1.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.659
DSCC1	PCNA	ENSOCUP00000015422	ENSOCUP00000003512	DNA replication and sister chromatid cohesion 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.906
DSCC1	RAD17	ENSOCUP00000015422	ENSOCUP00000037201	DNA replication and sister chromatid cohesion 1.	RAD17 checkpoint clamp loader component.	0.832
DSCC1	RFC1	ENSOCUP00000015422	ENSOCUP00000004099	DNA replication and sister chromatid cohesion 1.	Replication factor C subunit 1.	0.829
DSCC1	RFC2	ENSOCUP00000015422	ENSOCUP00000041420	DNA replication and sister chromatid cohesion 1.	Replication factor C subunit 2.	0.986
DSCC1	RFC3	ENSOCUP00000015422	ENSOCUP00000003142	DNA replication and sister chromatid cohesion 1.	Replication factor C subunit 3.	0.993
DSCC1	RFC4	ENSOCUP00000015422	ENSOCUP00000004340	DNA replication and sister chromatid cohesion 1.	Replication factor C subunit 4.	0.993
DSCC1	RFC5	ENSOCUP00000015422	ENSOCUP00000008939	DNA replication and sister chromatid cohesion 1.	Replication factor C subunit 5.	0.990
FEN1	ATAD5	ENSOCUP00000002851	ENSOCUP00000021311	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	ATPase family AAA domain containing 5.	0.940