| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYP19A1 | CYP1A1 | ENSOCUP00000010591 | ENSOCUP00000015239 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.954 |
| CYP19A1 | HSD17B12 | ENSOCUP00000010591 | ENSOCUP00000016136 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.955 |
| CYP19A1 | HSD17B2 | ENSOCUP00000010591 | ENSOCUP00000014316 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.965 |
| CYP19A1 | HSD17B8 | ENSOCUP00000010591 | ENSOCUP00000017884 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Hydroxysteroid 17-beta dehydrogenase 8. | 0.942 |
| CYP19A1 | LOC100338508 | ENSOCUP00000010591 | ENSOCUP00000011815 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.938 |
| CYP19A1 | LOC100351592 | ENSOCUP00000010591 | ENSOCUP00000026264 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.938 |
| CYP19A1 | LOC100357038 | ENSOCUP00000010591 | ENSOCUP00000025441 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.938 |
| CYP19A1 | SULT1E1 | ENSOCUP00000010591 | ENSOCUP00000004352 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.946 |
| CYP19A1 | UGT1 | ENSOCUP00000010591 | ENSOCUP00000033104 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyltransferase family. | 0.931 |
| CYP19A1 | UGT2C1 | ENSOCUP00000010591 | ENSOCUP00000023419 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | UDP-glucuronosyltransferase 2C1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.937 |
| CYP1A1 | CYP19A1 | ENSOCUP00000015239 | ENSOCUP00000010591 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. | 0.954 |
| CYP1A1 | HSD17B12 | ENSOCUP00000015239 | ENSOCUP00000016136 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.924 |
| CYP1A1 | HSD17B2 | ENSOCUP00000015239 | ENSOCUP00000014316 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.937 |
| CYP1A1 | HSD17B8 | ENSOCUP00000015239 | ENSOCUP00000017884 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Hydroxysteroid 17-beta dehydrogenase 8. | 0.932 |
| CYP1A1 | LOC100338508 | ENSOCUP00000015239 | ENSOCUP00000011815 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.973 |
| CYP1A1 | LOC100351592 | ENSOCUP00000015239 | ENSOCUP00000026264 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.973 |
| CYP1A1 | LOC100357038 | ENSOCUP00000015239 | ENSOCUP00000025441 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.973 |
| CYP1A1 | SULT1E1 | ENSOCUP00000015239 | ENSOCUP00000004352 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Sulfotransferase; Belongs to the sulfotransferase 1 family. | 0.938 |
| CYP1A1 | UGT1 | ENSOCUP00000015239 | ENSOCUP00000033104 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyltransferase family. | 0.977 |
| CYP1A1 | UGT2C1 | ENSOCUP00000015239 | ENSOCUP00000023419 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | UDP-glucuronosyltransferase 2C1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.973 |