Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DHCR2424-dehydrocholesterol reductase. (516 aa)    
Predicted Functional Partners:
CYP51A1
Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 0.985
SC5D
Sterol-C5-desaturase; Belongs to the sterol desaturase family.
   
 
 0.978
LSS
Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.
   
 
 0.977
TM7SF2
Uncharacterized protein.
   
 0.974
MSMO1
Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.
   
 
 0.951
LBR
Lamin B receptor.
   
 0.950
CYP7A1
Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]
   
 0.930
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 
 0.924
CYP46A1
Cytochrome P450 family 46 subfamily A member 1.
    
 0.922
SOAT1
O-acyltransferase.
     
 0.903
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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