WNT8A protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

WNT8A

Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)

Predicted Functional Partners:

LRP6

0.987

PORCN

0.958

WIF1

0.936

FZD8

0.936

FZD5

0.929

GPC3

0.916

FZD2

0.909

WLS

0.907

CER1

0.906

FZD4

0.886

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CER1	WNT8A	ENSOCUP00000008936	ENSOCUP00000004500	Cerberus 1, DAN family BMP antagonist.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.906
FZD2	FZD4	ENSOCUP00000012657	ENSOCUP00000043148	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.465
FZD2	LRP6	ENSOCUP00000012657	ENSOCUP00000002615	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.988
FZD2	PORCN	ENSOCUP00000012657	ENSOCUP00000013143	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.	0.442
FZD2	WIF1	ENSOCUP00000012657	ENSOCUP00000012816	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	WNT inhibitory factor 1.	0.581
FZD2	WNT8A	ENSOCUP00000012657	ENSOCUP00000004500	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.909
FZD4	FZD2	ENSOCUP00000043148	ENSOCUP00000012657	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.465
FZD4	LRP6	ENSOCUP00000043148	ENSOCUP00000002615	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.998
FZD4	WIF1	ENSOCUP00000043148	ENSOCUP00000012816	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	WNT inhibitory factor 1.	0.589
FZD4	WLS	ENSOCUP00000043148	ENSOCUP00000036042	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt ligand secretion mediator.	0.400
FZD4	WNT8A	ENSOCUP00000043148	ENSOCUP00000004500	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.886
FZD5	LRP6	ENSOCUP00000017638	ENSOCUP00000002615	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.987
FZD5	PORCN	ENSOCUP00000017638	ENSOCUP00000013143	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.	0.509
FZD5	WIF1	ENSOCUP00000017638	ENSOCUP00000012816	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	WNT inhibitory factor 1.	0.465
FZD5	WLS	ENSOCUP00000017638	ENSOCUP00000036042	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Wnt ligand secretion mediator.	0.410
FZD5	WNT8A	ENSOCUP00000017638	ENSOCUP00000004500	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.929
FZD8	LRP6	ENSOCUP00000026099	ENSOCUP00000002615	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.985
FZD8	WIF1	ENSOCUP00000026099	ENSOCUP00000012816	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family.	WNT inhibitory factor 1.	0.443
FZD8	WNT8A	ENSOCUP00000026099	ENSOCUP00000004500	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.936
GPC3	WNT8A	ENSOCUP00000001504	ENSOCUP00000004500	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.916

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.945

expected number of edges:

13

PPI enrichment p-value:

0.000238

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005985

Sucrose metabolic process

3 of 3

2.23

1.38

0.0025

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 28

1.39

0.96

0.0060

GO:0005975

Carbohydrate metabolic process

6 of 138

0.87

0.63

0.0060

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004564

Beta-fructofuranosidase activity

3 of 3

2.23

1.65

0.00074

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

4 of 21

1.51

1.3

0.00088

GO:0004553

Hydrolase activity, hydrolyzing O-glycosyl compounds

5 of 36

1.38

1.22

0.00074

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

5 of 58

1.17

1.0

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1197

Mixed, incl. Glycosidase, and Amino sugar metabolic process

7 of 16

1.87

3.76

2.85e-10

CL:1196

Import across plasma membrane, and Glycosidase

9 of 31

1.7

3.64

3.74e-12

CL:1195

Mixed, incl. Phosphotransferase system (PTS), and Pentose phosphate pathway

10 of 60

1.46

2.76

3.84e-12

CL:1194

Mixed, incl. Phosphotransferase system (PTS), and Glycolysis / Gluconeogenesis

11 of 83

1.36

2.45

1.10e-12

CL:1218

Glycosidase, and Mannose-6-phosphate isomerase, type I

2 of 5

1.84

0.79

0.0308

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00500

Starch and sucrose metabolism

6 of 69

1.17

0.00012

map02060

Phosphotransferase system (PTS)

4 of 30

1.36

1.14

0.0013

map00051

Fructose and mannose metabolism

3 of 21

1.39

0.89

0.0091

map00052

Galactose metabolism

3 of 25

1.31

0.83

0.0109

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

4 of 13

1.72

1.66

0.00022

KW-0598

Phosphotransferase system

3 of 12

1.63

1.09

0.0050

KW-0119

Carbohydrate metabolism

3 of 19

1.43

0.88

0.0111

KW-0762

Sugar transport

2 of 7

1.69

0.7

0.0426

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00367

Phosphotransferase system, EIIB

2 of 2

2.23

0.71

0.0495

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023296

Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

3 of 3

2.23

1.39

0.0024

IPR013189

Glycosyl hydrolase family 32, C-terminal

3 of 3

2.23

1.39

0.0024

IPR013148

Glycosyl hydrolase family 32, N-terminal

3 of 3

2.23

1.39

0.0024

IPR006232

Sucrose-6-phosphate hydrolase

3 of 3

2.23

1.39

0.0024

IPR001362

Glycoside hydrolase, family 32

3 of 3

2.23

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00640

Glycosyl hydrolases family 32

3 of 3

2.23

1.9

0.00023

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About