Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Experiments
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[Homology]
Score
PDGFRLPlatelet derived growth factor receptor like. (352 aa)    
Predicted Functional Partners:
NRP2
Neuropilin; Belongs to the neuropilin family.
     
 0.678
GRB2
Growth factor receptor bound protein 2.
   
 0.644
PDGFB
Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
   
 0.629
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.610
LOC100345250
Uncharacterized protein.
    
 0.610
GDNF
Glial cell derived neurotrophic factor.
    
 0.609
RASA1
RAS p21 protein activator 1.
   
  0.600
PDGFRB
Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
   
 0.597
PDGFA
Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...]
   
 0.578
VEGFA
Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family.
    
 0.572
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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