PPP2CB protein (Oryctolagus cuniculus) - STRING interaction network

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Score

PPP2CB

Serine/threonine-protein phosphatase. (350 aa)

Predicted Functional Partners:

PPP2R1A

0.986

PPP2R1B

0.985

PPP2R2B

0.880

LCMT1

0.878

PPP2R2A

0.872

PPME1

0.867

PPP2R5D

0.850

PTPA

0.842

PPP2R5A

0.830

PPP2R5B

0.826

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCMT1	PPME1	ENSOCUP00000044510	ENSOCUP00000022794	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	0.924
LCMT1	PPP2CB	ENSOCUP00000044510	ENSOCUP00000046534	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Serine/threonine-protein phosphatase.	0.878
LCMT1	PPP2R1A	ENSOCUP00000044510	ENSOCUP00000014689	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Protein phosphatase 2 scaffold subunit Aalpha.	0.810
LCMT1	PPP2R1B	ENSOCUP00000044510	ENSOCUP00000041612	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Protein phosphatase 2 scaffold subunit Abeta.	0.818
LCMT1	PPP2R2A	ENSOCUP00000044510	ENSOCUP00000035053	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.880
LCMT1	PPP2R2B	ENSOCUP00000044510	ENSOCUP00000028847	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.727
LCMT1	PPP2R5D	ENSOCUP00000044510	ENSOCUP00000001342	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	0.476
LCMT1	PTPA	ENSOCUP00000044510	ENSOCUP00000044909	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...]	0.906
PPME1	LCMT1	ENSOCUP00000022794	ENSOCUP00000044510	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	0.924
PPME1	PPP2CB	ENSOCUP00000022794	ENSOCUP00000046534	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase.	0.867
PPME1	PPP2R1A	ENSOCUP00000022794	ENSOCUP00000014689	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Protein phosphatase 2 scaffold subunit Aalpha.	0.894
PPME1	PPP2R1B	ENSOCUP00000022794	ENSOCUP00000041612	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Protein phosphatase 2 scaffold subunit Abeta.	0.911
PPME1	PPP2R2A	ENSOCUP00000022794	ENSOCUP00000035053	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.798
PPME1	PPP2R2B	ENSOCUP00000022794	ENSOCUP00000028847	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.684
PPME1	PPP2R5A	ENSOCUP00000022794	ENSOCUP00000037263	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.634
PPME1	PPP2R5B	ENSOCUP00000022794	ENSOCUP00000021664	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.	0.532
PPME1	PPP2R5D	ENSOCUP00000022794	ENSOCUP00000001342	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family.	0.762
PPME1	PTPA	ENSOCUP00000022794	ENSOCUP00000044909	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...]	0.747
PPP2CB	LCMT1	ENSOCUP00000046534	ENSOCUP00000044510	Serine/threonine-protein phosphatase.	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.	0.878
PPP2CB	PPME1	ENSOCUP00000046534	ENSOCUP00000022794	Serine/threonine-protein phosphatase.	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	0.867