Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)    
Predicted Functional Partners:
SEL1L
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 0.973
UBE2G2
Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.965
SYVN1
Synoviolin 1.
    
 0.956
OS9
OS9 endoplasmic reticulum lectin.
   
 0.919
UBA1
Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (By similarity).
   
 0.875
ERLEC1
Endoplasmic reticulum lectin 1.
   
 
 0.862
AUP1
AUP1 lipid droplet regulating VLDL assembly factor.
   
 
 0.853
DERL2
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
   
 
 0.848
UBE2H
Ubiquitin conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.847
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
   
 0.844
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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