node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | CTRL | ENSOCUP00000009130 | ENSOCUP00000040851 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Chymotrypsin like; Belongs to the peptidase S1 family. | 0.617 |
APP | KLK11 | ENSOCUP00000009130 | ENSOCUP00000004592 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | 0.617 |
CCDC25 | KLK11 | ENSOCUP00000030823 | ENSOCUP00000004592 | Coiled-coil domain containing 25. | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | 0.696 |
CTRL | APP | ENSOCUP00000040851 | ENSOCUP00000009130 | Chymotrypsin like; Belongs to the peptidase S1 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.617 |
CTRL | KLK11 | ENSOCUP00000040851 | ENSOCUP00000004592 | Chymotrypsin like; Belongs to the peptidase S1 family. | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | 0.525 |
CTRL | LOC100340108 | ENSOCUP00000040851 | ENSOCUP00000035493 | Chymotrypsin like; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.437 |
CTRL | MET | ENSOCUP00000040851 | ENSOCUP00000003111 | Chymotrypsin like; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.537 |
CTRL | MST1R | ENSOCUP00000040851 | ENSOCUP00000008078 | Chymotrypsin like; Belongs to the peptidase S1 family. | Macrophage stimulating 1 receptor. | 0.539 |
KIF12 | KLK11 | ENSOCUP00000049794 | ENSOCUP00000004592 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | 0.536 |
KIF12 | YPEL1 | ENSOCUP00000049794 | ENSOCUP00000025286 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | Protein yippee-like; Belongs to the yippee family. | 0.650 |
KLK11 | APP | ENSOCUP00000004592 | ENSOCUP00000009130 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.617 |
KLK11 | CCDC25 | ENSOCUP00000004592 | ENSOCUP00000030823 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Coiled-coil domain containing 25. | 0.696 |
KLK11 | CTRL | ENSOCUP00000004592 | ENSOCUP00000040851 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Chymotrypsin like; Belongs to the peptidase S1 family. | 0.525 |
KLK11 | KIF12 | ENSOCUP00000004592 | ENSOCUP00000049794 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.536 |
KLK11 | LOC100340108 | ENSOCUP00000004592 | ENSOCUP00000035493 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.545 |
KLK11 | MET | ENSOCUP00000004592 | ENSOCUP00000003111 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.537 |
KLK11 | MST1R | ENSOCUP00000004592 | ENSOCUP00000008078 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Macrophage stimulating 1 receptor. | 0.539 |
KLK11 | SPINK6 | ENSOCUP00000004592 | ENSOCUP00000007603 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Serine peptidase inhibitor, Kazal type 6. | 0.526 |
KLK11 | TFPI | ENSOCUP00000004592 | ENSOCUP00000007133 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. | 0.574 |
KLK11 | YPEL1 | ENSOCUP00000004592 | ENSOCUP00000025286 | Kallikrein related peptidase 11; Belongs to the peptidase S1 family. | Protein yippee-like; Belongs to the yippee family. | 0.578 |