node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | CNTF | ENSOCUP00000036666 | ENSOCUP00000004675 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | 0.923 |
BDNF | CNTFR | ENSOCUP00000036666 | ENSOCUP00000043912 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Ciliary neurotrophic factor receptor. | 0.482 |
BDNF | EPO | ENSOCUP00000036666 | ENSOCUP00000004681 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.670 |
BDNF | GDNF | ENSOCUP00000036666 | ENSOCUP00000002636 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Glial cell derived neurotrophic factor. | 0.966 |
BDNF | LEP | ENSOCUP00000036666 | ENSOCUP00000008782 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.667 |
BDNF | LIF | ENSOCUP00000036666 | ENSOCUP00000003262 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | LIF interleukin 6 family cytokine. | 0.649 |
CNTF | BDNF | ENSOCUP00000004675 | ENSOCUP00000036666 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.923 |
CNTF | CNTFR | ENSOCUP00000004675 | ENSOCUP00000043912 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Ciliary neurotrophic factor receptor. | 0.999 |
CNTF | CSF3 | ENSOCUP00000004675 | ENSOCUP00000008356 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Colony stimulating factor 3. | 0.918 |
CNTF | EPO | ENSOCUP00000004675 | ENSOCUP00000004681 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.926 |
CNTF | GDNF | ENSOCUP00000004675 | ENSOCUP00000002636 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Glial cell derived neurotrophic factor. | 0.918 |
CNTF | IL6ST | ENSOCUP00000004675 | ENSOCUP00000006777 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Interleukin 6 signal transducer. | 0.949 |
CNTF | LEP | ENSOCUP00000004675 | ENSOCUP00000008782 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.953 |
CNTF | LIF | ENSOCUP00000004675 | ENSOCUP00000003262 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | LIF interleukin 6 family cytokine. | 0.915 |
CNTF | LIFR | ENSOCUP00000004675 | ENSOCUP00000002891 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | LIF receptor subunit alpha. | 0.997 |
CNTF | PRL | ENSOCUP00000004675 | ENSOCUP00000001120 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. | 0.915 |
CNTFR | BDNF | ENSOCUP00000043912 | ENSOCUP00000036666 | Ciliary neurotrophic factor receptor. | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | 0.482 |
CNTFR | CNTF | ENSOCUP00000043912 | ENSOCUP00000004675 | Ciliary neurotrophic factor receptor. | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. | 0.999 |
CNTFR | CSF3 | ENSOCUP00000043912 | ENSOCUP00000008356 | Ciliary neurotrophic factor receptor. | Colony stimulating factor 3. | 0.676 |
CNTFR | EPO | ENSOCUP00000043912 | ENSOCUP00000004681 | Ciliary neurotrophic factor receptor. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.656 |