Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)    
Predicted Functional Partners:
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.998
CDKN1B
Cyclin dependent kinase inhibitor 1B.
   
 0.994
CDKN1A
Uncharacterized protein.
   
 0.992
CDK3
Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.
   
 0.982
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.980
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.979
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.979
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.964
CDC25A
Cell division cycle 25A.
   
 0.960
RBL2
RB transcriptional corepressor like 2.
   
 0.959
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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