NLRP3 protein (Oryctolagus cuniculus) - STRING interaction network

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NLRP3

NLR family pyrin domain containing 3. (1046 aa)

Predicted Functional Partners:

LOC100358658

0.952

CASP1

0.937

GSDMD

0.912

PYCARD

0.838

IL18

0.827

TNF

0.827

IL1B

0.816

ENSOCUP00000023657

0.749

ENSOCUP00000033999

0.749

HMGB1

0.704

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	ENSOCUP00000023657	ENSOCUP00000000956	ENSOCUP00000023657	Uncharacterized protein; Belongs to the peptidase C14A family.	annotation not available	0.646
CASP1	ENSOCUP00000033999	ENSOCUP00000000956	ENSOCUP00000033999	Uncharacterized protein; Belongs to the peptidase C14A family.	annotation not available	0.646
CASP1	GSDMD	ENSOCUP00000000956	ENSOCUP00000001621	Uncharacterized protein; Belongs to the peptidase C14A family.	Gasdermin D.	0.998
CASP1	HMGB1	ENSOCUP00000000956	ENSOCUP00000022987	Uncharacterized protein; Belongs to the peptidase C14A family.	High-mobility group box 1 (Predicted).	0.678
CASP1	IL18	ENSOCUP00000000956	ENSOCUP00000004555	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.997
CASP1	IL1B	ENSOCUP00000000956	ENSOCUP00000021869	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.998
CASP1	LOC100358658	ENSOCUP00000000956	ENSOCUP00000026479	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.682
CASP1	NLRP3	ENSOCUP00000000956	ENSOCUP00000004733	Uncharacterized protein; Belongs to the peptidase C14A family.	NLR family pyrin domain containing 3.	0.937
CASP1	PYCARD	ENSOCUP00000000956	ENSOCUP00000003881	Uncharacterized protein; Belongs to the peptidase C14A family.	PYD and CARD domain containing.	0.998
CASP1	TNF	ENSOCUP00000000956	ENSOCUP00000005787	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.704
ENSOCUP00000023657	CASP1	ENSOCUP00000023657	ENSOCUP00000000956	annotation not available	Uncharacterized protein; Belongs to the peptidase C14A family.	0.646
ENSOCUP00000023657	GSDMD	ENSOCUP00000023657	ENSOCUP00000001621	annotation not available	Gasdermin D.	0.744
ENSOCUP00000023657	IL18	ENSOCUP00000023657	ENSOCUP00000004555	annotation not available	Uncharacterized protein.	0.571
ENSOCUP00000023657	IL1B	ENSOCUP00000023657	ENSOCUP00000021869	annotation not available	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.687
ENSOCUP00000023657	LOC100358658	ENSOCUP00000023657	ENSOCUP00000026479	annotation not available	Uncharacterized protein; Belongs to the peptidase C14A family.	0.671
ENSOCUP00000023657	NLRP3	ENSOCUP00000023657	ENSOCUP00000004733	annotation not available	NLR family pyrin domain containing 3.	0.749
ENSOCUP00000023657	TNF	ENSOCUP00000023657	ENSOCUP00000005787	annotation not available	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.827
ENSOCUP00000033999	CASP1	ENSOCUP00000033999	ENSOCUP00000000956	annotation not available	Uncharacterized protein; Belongs to the peptidase C14A family.	0.646
ENSOCUP00000033999	GSDMD	ENSOCUP00000033999	ENSOCUP00000001621	annotation not available	Gasdermin D.	0.744
ENSOCUP00000033999	IL18	ENSOCUP00000033999	ENSOCUP00000004555	annotation not available	Uncharacterized protein.	0.571