AKR1C1L protein (Oryctolagus cuniculus) - STRING interaction network

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AKR1C1L

Aldo_ket_red domain-containing protein. (322 aa)

Predicted Functional Partners:

AKR1D1

0.567

AKR1D1-2

0.567

SRD5A2

0.561

SRD5A1

0.561

DHDH

0.555

SORD

0.551

CYP3A6

0.542

HPGDS

0.537

HSD11B2

0.537

HSD17B8

0.535

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1C1L	AKR1D1	ENSOCUP00000005047	ENSOCUP00000014594	Aldo_ket_red domain-containing protein.	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	0.567
AKR1C1L	AKR1D1-2	ENSOCUP00000005047	ENSOCUP00000017752	Aldo_ket_red domain-containing protein.	Aldo-keto reductase family 1 member D1.	0.567
AKR1C1L	CYP3A6	ENSOCUP00000005047	ENSOCUP00000034396	Aldo_ket_red domain-containing protein.	Cytochrome P450 3A6; Exhibits progesterone 6 beta-hydroxylase activity.	0.542
AKR1C1L	DHDH	ENSOCUP00000005047	ENSOCUP00000005550	Aldo_ket_red domain-containing protein.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.555
AKR1C1L	HPGDS	ENSOCUP00000005047	ENSOCUP00000014861	Aldo_ket_red domain-containing protein.	Hematopoietic prostaglandin D synthase.	0.537
AKR1C1L	HSD11B2	ENSOCUP00000005047	ENSOCUP00000037332	Aldo_ket_red domain-containing protein.	Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.	0.537
AKR1C1L	HSD17B8	ENSOCUP00000005047	ENSOCUP00000017884	Aldo_ket_red domain-containing protein.	Hydroxysteroid 17-beta dehydrogenase 8.	0.535
AKR1C1L	SORD	ENSOCUP00000005047	ENSOCUP00000012246	Aldo_ket_red domain-containing protein.	Sorbitol dehydrogenase.	0.551
AKR1C1L	SRD5A1	ENSOCUP00000005047	ENSOCUP00000014623	Aldo_ket_red domain-containing protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.561
AKR1C1L	SRD5A2	ENSOCUP00000005047	ENSOCUP00000001070	Aldo_ket_red domain-containing protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.561
AKR1D1	AKR1C1L	ENSOCUP00000014594	ENSOCUP00000005047	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Aldo_ket_red domain-containing protein.	0.567
AKR1D1	CYP3A6	ENSOCUP00000014594	ENSOCUP00000034396	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Cytochrome P450 3A6; Exhibits progesterone 6 beta-hydroxylase activity.	0.524
AKR1D1	DHDH	ENSOCUP00000014594	ENSOCUP00000005550	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.616
AKR1D1	HPGDS	ENSOCUP00000014594	ENSOCUP00000014861	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Hematopoietic prostaglandin D synthase.	0.519
AKR1D1	HSD11B2	ENSOCUP00000014594	ENSOCUP00000037332	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.	0.847
AKR1D1	HSD17B8	ENSOCUP00000014594	ENSOCUP00000017884	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Hydroxysteroid 17-beta dehydrogenase 8.	0.786
AKR1D1	SORD	ENSOCUP00000014594	ENSOCUP00000012246	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	Sorbitol dehydrogenase.	0.551
AKR1D1	SRD5A1	ENSOCUP00000014594	ENSOCUP00000014623	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.918
AKR1D1	SRD5A2	ENSOCUP00000014594	ENSOCUP00000001070	Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.908
AKR1D1-2	AKR1C1L	ENSOCUP00000017752	ENSOCUP00000005047	Aldo-keto reductase family 1 member D1.	Aldo_ket_red domain-containing protein.	0.567