node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENO1 | HK2 | ENSOCUP00000035294 | ENSOCUP00000037331 | Uncharacterized protein. | Hexokinase 2. | 0.750 |
ENO1 | LDHA | ENSOCUP00000035294 | ENSOCUP00000013690 | Uncharacterized protein. | L-lactate dehydrogenase A chain. | 0.924 |
ENO1 | PKM | ENSOCUP00000035294 | ENSOCUP00000005301 | Uncharacterized protein. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.932 |
ENO1 | SLC2A1 | ENSOCUP00000035294 | ENSOCUP00000027075 | Uncharacterized protein. | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | 0.712 |
G1T017_RABIT | SLC1A7 | ENSOCUP00000009309 | ENSOCUP00000002220 | Amino acid transporter. | Amino acid transporter. | 0.946 |
G1T017_RABIT | SLC2A1 | ENSOCUP00000009309 | ENSOCUP00000027075 | Amino acid transporter. | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | 0.685 |
HK2 | ENO1 | ENSOCUP00000037331 | ENSOCUP00000035294 | Hexokinase 2. | Uncharacterized protein. | 0.750 |
HK2 | LDHA | ENSOCUP00000037331 | ENSOCUP00000013690 | Hexokinase 2. | L-lactate dehydrogenase A chain. | 0.871 |
HK2 | PKM | ENSOCUP00000037331 | ENSOCUP00000005301 | Hexokinase 2. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.930 |
HK2 | SLC2A1 | ENSOCUP00000037331 | ENSOCUP00000027075 | Hexokinase 2. | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | 0.761 |
LDHA | ENO1 | ENSOCUP00000013690 | ENSOCUP00000035294 | L-lactate dehydrogenase A chain. | Uncharacterized protein. | 0.924 |
LDHA | HK2 | ENSOCUP00000013690 | ENSOCUP00000037331 | L-lactate dehydrogenase A chain. | Hexokinase 2. | 0.871 |
LDHA | PKM | ENSOCUP00000013690 | ENSOCUP00000005301 | L-lactate dehydrogenase A chain. | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | 0.946 |
LDHA | SLC2A1 | ENSOCUP00000013690 | ENSOCUP00000027075 | L-lactate dehydrogenase A chain. | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | 0.821 |
PKM | ENO1 | ENSOCUP00000005301 | ENSOCUP00000035294 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | Uncharacterized protein. | 0.932 |
PKM | HK2 | ENSOCUP00000005301 | ENSOCUP00000037331 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | Hexokinase 2. | 0.930 |
PKM | LDHA | ENSOCUP00000005301 | ENSOCUP00000013690 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | L-lactate dehydrogenase A chain. | 0.946 |
PKM | SLC2A1 | ENSOCUP00000005301 | ENSOCUP00000027075 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. | 0.747 |
PKM | TP53 | ENSOCUP00000005301 | ENSOCUP00000000989 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (By similarity). | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.426 |
SLC1A2 | SLC1A7 | ENSOCUP00000000621 | ENSOCUP00000002220 | Amino acid transporter. | Amino acid transporter. | 0.908 |