STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPX1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown. (200 aa)    
Predicted Functional Partners:
GSR
Glutathione-disulfide reductase.
  
 0.987
PRDX6
Thioredoxin domain-containing protein.
   
 0.974
GPX7
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
 
0.967
GPX8
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
 
0.957
ALOX15
Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...]
     
 0.936
GPX2
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
  
0.934
PPARGC1A
PPARG coactivator 1 alpha.
     
 0.929
SOD1
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
   
 0.922
GSS
Glutathione synthetase.
   
 
 0.918
GPX3
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
  
0.915
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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