Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IL18RAPInterleukin 18 receptor accessory protein. (599 aa)    
Predicted Functional Partners:
IL18R1
Uncharacterized protein.
   
0.995
IL18
Uncharacterized protein.
   
 0.948
IL1B
Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.
     
 0.896
IL37
Interleukin-1.
    
 0.889
IL1R2
Interleukin 1 receptor type 2.
   
 
 0.866
PIGA
Phosphatidylinositol glycan anchor biosynthesis class A.
    
   0.735
MYD88
Uncharacterized protein.
   
 
 0.716
IL36RN
Interleukin-1.
    
 0.630
IL18BP
Interleukin 18 binding protein isoform 1.
     
 0.579
IL7R
Interleukin 7 receptor.
  
  
 0.543
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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