STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAD6MH2 domain-containing protein. (220 aa)    
Predicted Functional Partners:
SMURF1
E3 ubiquitin-protein ligase.
   
 0.999
SMURF2
E3 ubiquitin-protein ligase.
    
 0.996
SMAD1
Mothers against decapentaplegic homolog.
   
0.987
SMAD5
Mothers against decapentaplegic homolog.
   
0.968
SMAD2
Mothers against decapentaplegic homolog.
   
0.967
SMAD3
SMAD family member 3.
   
0.952
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
   
 0.903
BMP4
Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
   
 0.861
SMAD4
Mothers against decapentaplegic homolog.
    
0.845
BMPR1A
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
   
 0.839
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.