PPP4R2 protein (Oryctolagus cuniculus) - STRING interaction network

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PPP4R2

Serine/threonine-protein phosphatase 4 regulatory subunit 2. (432 aa)

Predicted Functional Partners:

PPP4R3A

0.987

PPP4C

0.985

PPP4R3B

0.898

PPP4R1

0.867

PTPA

0.806

PPP4R3C

0.721

PPP3CB

0.691

GXYLT2

0.660

PPP2R2A

0.634

SUPT5H

0.625

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GXYLT2	PPP4R2	ENSOCUP00000014358	ENSOCUP00000005396	Glucoside xylosyltransferase 2.	Serine/threonine-protein phosphatase 4 regulatory subunit 2.	0.660
PPP2R2A	PPP3CB	ENSOCUP00000035053	ENSOCUP00000019808	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase.	0.889
PPP2R2A	PPP4C	ENSOCUP00000035053	ENSOCUP00000005480	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]	0.885
PPP2R2A	PPP4R1	ENSOCUP00000035053	ENSOCUP00000029628	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein phosphatase 4 regulatory subunit 1.	0.858
PPP2R2A	PPP4R2	ENSOCUP00000035053	ENSOCUP00000005396	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase 4 regulatory subunit 2.	0.634
PPP2R2A	PPP4R3A	ENSOCUP00000035053	ENSOCUP00000015262	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein phosphatase 4 regulatory subunit 3A.	0.528
PPP2R2A	PPP4R3B	ENSOCUP00000035053	ENSOCUP00000005953	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Protein phosphatase 4 regulatory subunit 3B.	0.510
PPP2R2A	PTPA	ENSOCUP00000035053	ENSOCUP00000044909	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...]	0.775
PPP3CB	PPP2R2A	ENSOCUP00000019808	ENSOCUP00000035053	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.889
PPP3CB	PPP4R1	ENSOCUP00000019808	ENSOCUP00000029628	Serine/threonine-protein phosphatase.	Protein phosphatase 4 regulatory subunit 1.	0.739
PPP3CB	PPP4R2	ENSOCUP00000019808	ENSOCUP00000005396	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase 4 regulatory subunit 2.	0.691
PPP3CB	PPP4R3A	ENSOCUP00000019808	ENSOCUP00000015262	Serine/threonine-protein phosphatase.	Protein phosphatase 4 regulatory subunit 3A.	0.601
PPP3CB	PPP4R3B	ENSOCUP00000019808	ENSOCUP00000005953	Serine/threonine-protein phosphatase.	Protein phosphatase 4 regulatory subunit 3B.	0.614
PPP3CB	PPP4R3C	ENSOCUP00000019808	ENSOCUP00000022974	Serine/threonine-protein phosphatase.	Protein phosphatase 4 regulatory subunit 3C.	0.402
PPP3CB	PTPA	ENSOCUP00000019808	ENSOCUP00000044909	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...]	0.778
PPP4C	PPP2R2A	ENSOCUP00000005480	ENSOCUP00000035053	Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.885
PPP4C	PPP4R1	ENSOCUP00000005480	ENSOCUP00000029628	Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]	Protein phosphatase 4 regulatory subunit 1.	0.933
PPP4C	PPP4R2	ENSOCUP00000005480	ENSOCUP00000005396	Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]	Serine/threonine-protein phosphatase 4 regulatory subunit 2.	0.985
PPP4C	PPP4R3A	ENSOCUP00000005480	ENSOCUP00000015262	Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]	Protein phosphatase 4 regulatory subunit 3A.	0.997
PPP4C	PPP4R3B	ENSOCUP00000005480	ENSOCUP00000005953	Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...]	Protein phosphatase 4 regulatory subunit 3B.	0.988