node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL-15L | IL15RA | ENSOCUP00000020864 | ENSOCUP00000005404 | Interleukin 15-like protein. | Sushi domain-containing protein. | 0.886 |
IL-15L | IL2RG | ENSOCUP00000020864 | ENSOCUP00000018882 | Interleukin 15-like protein. | Uncharacterized protein. | 0.583 |
IL-15L | IL9 | ENSOCUP00000020864 | ENSOCUP00000005508 | Interleukin 15-like protein. | Interleukin 9. | 0.536 |
IL-15L | LOC100358749 | ENSOCUP00000020864 | ENSOCUP00000006221 | Interleukin 15-like protein. | Sushi domain-containing protein. | 0.886 |
IL15 | IL15RA | ENSOCUP00000007620 | ENSOCUP00000005404 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Sushi domain-containing protein. | 0.999 |
IL15 | IL2 | ENSOCUP00000007620 | ENSOCUP00000008701 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.854 |
IL15 | IL2RG | ENSOCUP00000007620 | ENSOCUP00000018882 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Uncharacterized protein. | 0.996 |
IL15 | IL4 | ENSOCUP00000007620 | ENSOCUP00000025135 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.871 |
IL15 | IL6 | ENSOCUP00000007620 | ENSOCUP00000017266 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.921 |
IL15 | IL9 | ENSOCUP00000007620 | ENSOCUP00000005508 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Interleukin 9. | 0.939 |
IL15 | JAK1 | ENSOCUP00000007620 | ENSOCUP00000005398 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Tyrosine-protein kinase. | 0.887 |
IL15 | JAK2 | ENSOCUP00000007620 | ENSOCUP00000014491 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Tyrosine-protein kinase. | 0.778 |
IL15 | LOC100358749 | ENSOCUP00000007620 | ENSOCUP00000006221 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | Sushi domain-containing protein. | 0.997 |
IL15RA | IL-15L | ENSOCUP00000005404 | ENSOCUP00000020864 | Sushi domain-containing protein. | Interleukin 15-like protein. | 0.886 |
IL15RA | IL15 | ENSOCUP00000005404 | ENSOCUP00000007620 | Sushi domain-containing protein. | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). | 0.999 |
IL15RA | IL2 | ENSOCUP00000005404 | ENSOCUP00000008701 | Sushi domain-containing protein. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.813 |
IL15RA | IL2RG | ENSOCUP00000005404 | ENSOCUP00000018882 | Sushi domain-containing protein. | Uncharacterized protein. | 0.965 |
IL15RA | IL4 | ENSOCUP00000005404 | ENSOCUP00000025135 | Sushi domain-containing protein. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.750 |
IL15RA | IL6 | ENSOCUP00000005404 | ENSOCUP00000017266 | Sushi domain-containing protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.754 |
IL15RA | IL9 | ENSOCUP00000005404 | ENSOCUP00000005508 | Sushi domain-containing protein. | Interleukin 9. | 0.768 |