| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGER | S100A6 | ENSOCUP00000017209 | ENSOCUP00000031840 | Advanced glycosylation end-product specific receptor. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). | 0.785 |
| AGER | S100B | ENSOCUP00000017209 | ENSOCUP00000001267 | Advanced glycosylation end-product specific receptor. | Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...] | 0.917 |
| AGER | S100P | ENSOCUP00000017209 | ENSOCUP00000005502 | Advanced glycosylation end-product specific receptor. | S100 calcium binding protein P. | 0.636 |
| ANXA1 | S100A6 | ENSOCUP00000016846 | ENSOCUP00000031840 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). | 0.892 |
| ANXA1 | S100P | ENSOCUP00000016846 | ENSOCUP00000005502 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] | S100 calcium binding protein P. | 0.656 |
| ANXA1 | S100a10 | ENSOCUP00000016846 | ENSOCUP00000004505 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. | 0.998 |
| S100A1 | S100A14 | ENSOCUP00000002387 | ENSOCUP00000002376 | Protein S100; Belongs to the S-100 family. | S100 calcium binding protein A14; Belongs to the S-100 family. | 0.882 |
| S100A1 | S100A3 | ENSOCUP00000002387 | ENSOCUP00000007470 | Protein S100; Belongs to the S-100 family. | S100 calcium binding protein A3. | 0.865 |
| S100A1 | S100A6 | ENSOCUP00000002387 | ENSOCUP00000031840 | Protein S100; Belongs to the S-100 family. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). | 0.864 |
| S100A1 | S100B | ENSOCUP00000002387 | ENSOCUP00000001267 | Protein S100; Belongs to the S-100 family. | Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...] | 0.932 |
| S100A1 | S100P | ENSOCUP00000002387 | ENSOCUP00000005502 | Protein S100; Belongs to the S-100 family. | S100 calcium binding protein P. | 0.838 |
| S100A1 | S100a10 | ENSOCUP00000002387 | ENSOCUP00000004505 | Protein S100; Belongs to the S-100 family. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. | 0.848 |
| S100A14 | S100A1 | ENSOCUP00000002376 | ENSOCUP00000002387 | S100 calcium binding protein A14; Belongs to the S-100 family. | Protein S100; Belongs to the S-100 family. | 0.882 |
| S100A14 | S100A3 | ENSOCUP00000002376 | ENSOCUP00000007470 | S100 calcium binding protein A14; Belongs to the S-100 family. | S100 calcium binding protein A3. | 0.950 |
| S100A14 | S100A6 | ENSOCUP00000002376 | ENSOCUP00000031840 | S100 calcium binding protein A14; Belongs to the S-100 family. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). | 0.914 |
| S100A14 | S100A8 | ENSOCUP00000002376 | ENSOCUP00000008245 | S100 calcium binding protein A14; Belongs to the S-100 family. | Protein S100; Belongs to the S-100 family. | 0.751 |
| S100A14 | S100P | ENSOCUP00000002376 | ENSOCUP00000005502 | S100 calcium binding protein A14; Belongs to the S-100 family. | S100 calcium binding protein P. | 0.687 |
| S100A14 | S100a10 | ENSOCUP00000002376 | ENSOCUP00000004505 | S100 calcium binding protein A14; Belongs to the S-100 family. | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. | 0.885 |
| S100A3 | S100A1 | ENSOCUP00000007470 | ENSOCUP00000002387 | S100 calcium binding protein A3. | Protein S100; Belongs to the S-100 family. | 0.865 |
| S100A3 | S100A14 | ENSOCUP00000007470 | ENSOCUP00000002376 | S100 calcium binding protein A3. | S100 calcium binding protein A14; Belongs to the S-100 family. | 0.950 |