NR0B2 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

NR0B2

Nuclear receptor subfamily 0 group B member 2. (260 aa)

Predicted Functional Partners:

HNF4A

0.943

NR5A2

0.876

NR1H4

0.868

NR5A1

0.859

ESRRG

0.840

CYP7A1

0.831

ENSOCUP00000027514

0.827

NR1H3

0.823

SIN3A

0.793

EID1

0.783

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP7A1	ENSOCUP00000027514	ENSOCUP00000010572	ENSOCUP00000027514	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Uncharacterized protein.	0.691
CYP7A1	HNF4A	ENSOCUP00000010572	ENSOCUP00000005917	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Hepatocyte nuclear factor 4 alpha.	0.737
CYP7A1	NR0B2	ENSOCUP00000010572	ENSOCUP00000005546	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Nuclear receptor subfamily 0 group B member 2.	0.831
CYP7A1	NR1H3	ENSOCUP00000010572	ENSOCUP00000001808	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Liver X receptor alpha.	0.838
CYP7A1	NR1H4	ENSOCUP00000010572	ENSOCUP00000006201	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Uncharacterized protein.	0.941
CYP7A1	NR5A1	ENSOCUP00000010572	ENSOCUP00000006784	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Nuclear receptor subfamily 5 group A member 1.	0.531
CYP7A1	NR5A2	ENSOCUP00000010572	ENSOCUP00000005400	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	Uncharacterized protein.	0.691
EID1	NR0B2	ENSOCUP00000018246	ENSOCUP00000005546	EP300 interacting inhibitor of differentiation 1.	Nuclear receptor subfamily 0 group B member 2.	0.783
ENSOCUP00000027514	CYP7A1	ENSOCUP00000027514	ENSOCUP00000010572	Uncharacterized protein.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.691
ENSOCUP00000027514	NR0B2	ENSOCUP00000027514	ENSOCUP00000005546	Uncharacterized protein.	Nuclear receptor subfamily 0 group B member 2.	0.827
ESRRG	NR0B2	ENSOCUP00000045110	ENSOCUP00000005546	Estrogen related receptor gamma.	Nuclear receptor subfamily 0 group B member 2.	0.840
HNF4A	CYP7A1	ENSOCUP00000005917	ENSOCUP00000010572	Hepatocyte nuclear factor 4 alpha.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.737
HNF4A	NR0B2	ENSOCUP00000005917	ENSOCUP00000005546	Hepatocyte nuclear factor 4 alpha.	Nuclear receptor subfamily 0 group B member 2.	0.943
HNF4A	NR1H3	ENSOCUP00000005917	ENSOCUP00000001808	Hepatocyte nuclear factor 4 alpha.	Liver X receptor alpha.	0.424
HNF4A	NR1H4	ENSOCUP00000005917	ENSOCUP00000006201	Hepatocyte nuclear factor 4 alpha.	Uncharacterized protein.	0.589
NR0B2	CYP7A1	ENSOCUP00000005546	ENSOCUP00000010572	Nuclear receptor subfamily 0 group B member 2.	Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis (Probable). Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha [...]	0.831
NR0B2	EID1	ENSOCUP00000005546	ENSOCUP00000018246	Nuclear receptor subfamily 0 group B member 2.	EP300 interacting inhibitor of differentiation 1.	0.783
NR0B2	ENSOCUP00000027514	ENSOCUP00000005546	ENSOCUP00000027514	Nuclear receptor subfamily 0 group B member 2.	Uncharacterized protein.	0.827
NR0B2	ESRRG	ENSOCUP00000005546	ENSOCUP00000045110	Nuclear receptor subfamily 0 group B member 2.	Estrogen related receptor gamma.	0.840
NR0B2	HNF4A	ENSOCUP00000005546	ENSOCUP00000005917	Nuclear receptor subfamily 0 group B member 2.	Hepatocyte nuclear factor 4 alpha.	0.943