Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SHC4SHC adaptor protein 4. (630 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
    
 0.987
GRB2
Growth factor receptor bound protein 2.
    
 0.938
ERBB2
Receptor protein-tyrosine kinase.
    
 0.922
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.922
ERBB4
Receptor protein-tyrosine kinase.
    
 0.922
GAB1
GRB2 associated binding protein 1.
    
 0.911
SHC3
SHC adaptor protein 3.
    
  0.909
IGF1R
Tyrosine-protein kinase receptor.
    
 0.904
INSR
Tyrosine-protein kinase receptor.
    
 0.904
MST1R
Macrophage stimulating 1 receptor.
   
 0.899
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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