SHC4 protein (Oryctolagus cuniculus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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textmining

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Score

SHC4

SHC adaptor protein 4. (630 aa)

Predicted Functional Partners:

EGFR

0.973

MET

0.965

ERBB2

0.965

ERBB3

0.965

ERBB4

0.965

GAB1

0.962

GRB2

0.958

INSR

0.954

SOS2

0.942

FGFR2

0.940

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSOCUP00000009041	ENSOCUP00000009117	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
EGFR	ERBB3	ENSOCUP00000009041	ENSOCUP00000014890	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.998
EGFR	ERBB4	ENSOCUP00000009041	ENSOCUP00000035750	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.944
EGFR	FGFR2	ENSOCUP00000009041	ENSOCUP00000034244	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.659
EGFR	GAB1	ENSOCUP00000009041	ENSOCUP00000002840	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.996
EGFR	GRB2	ENSOCUP00000009041	ENSOCUP00000042433	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999
EGFR	INSR	ENSOCUP00000009041	ENSOCUP00000042281	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.952
EGFR	MET	ENSOCUP00000009041	ENSOCUP00000003111	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.835
EGFR	SHC4	ENSOCUP00000009041	ENSOCUP00000005567	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.973
EGFR	SOS2	ENSOCUP00000009041	ENSOCUP00000005246	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.990
ERBB2	EGFR	ENSOCUP00000009117	ENSOCUP00000009041	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.999
ERBB2	ERBB3	ENSOCUP00000009117	ENSOCUP00000014890	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.999
ERBB2	ERBB4	ENSOCUP00000009117	ENSOCUP00000035750	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
ERBB2	FGFR2	ENSOCUP00000009117	ENSOCUP00000034244	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.504
ERBB2	GAB1	ENSOCUP00000009117	ENSOCUP00000002840	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.967
ERBB2	GRB2	ENSOCUP00000009117	ENSOCUP00000042433	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.997
ERBB2	INSR	ENSOCUP00000009117	ENSOCUP00000042281	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.966
ERBB2	MET	ENSOCUP00000009117	ENSOCUP00000003111	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.789
ERBB2	SHC4	ENSOCUP00000009117	ENSOCUP00000005567	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.965
ERBB2	SOS2	ENSOCUP00000009117	ENSOCUP00000005246	Receptor protein-tyrosine kinase.	SOS Ras/Rho guanine nucleotide exchange factor 2.	0.724