PLCB2 protein (Oryctolagus cuniculus) - STRING interaction network

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PLCB2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1157 aa)

Predicted Functional Partners:

GNAT3

0.979

PLCB1

0.962

ITPR3

0.944

GNB3

0.937

ITPR2

0.925

ITPKA

0.924

GNG4

0.914

GNB5

0.909

PIK3CG

0.908

GNAO1

0.907

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAO1	GNAT3	ENSOCUP00000040227	ENSOCUP00000022632	G protein subunit alpha o1.	G protein subunit alpha transducin 3.	0.773
GNAO1	GNB3	ENSOCUP00000040227	ENSOCUP00000011129	G protein subunit alpha o1.	G protein subunit beta 3.	0.972
GNAO1	GNB5	ENSOCUP00000040227	ENSOCUP00000010220	G protein subunit alpha o1.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.951
GNAO1	GNG4	ENSOCUP00000040227	ENSOCUP00000005907	G protein subunit alpha o1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.963
GNAO1	PIK3CG	ENSOCUP00000040227	ENSOCUP00000010960	G protein subunit alpha o1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.856
GNAO1	PLCB1	ENSOCUP00000040227	ENSOCUP00000036536	G protein subunit alpha o1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.905
GNAO1	PLCB2	ENSOCUP00000040227	ENSOCUP00000005658	G protein subunit alpha o1.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.907
GNAT3	GNAO1	ENSOCUP00000022632	ENSOCUP00000040227	G protein subunit alpha transducin 3.	G protein subunit alpha o1.	0.773
GNAT3	GNB3	ENSOCUP00000022632	ENSOCUP00000011129	G protein subunit alpha transducin 3.	G protein subunit beta 3.	0.971
GNAT3	GNB5	ENSOCUP00000022632	ENSOCUP00000010220	G protein subunit alpha transducin 3.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.708
GNAT3	GNG4	ENSOCUP00000022632	ENSOCUP00000005907	G protein subunit alpha transducin 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.795
GNAT3	ITPR3	ENSOCUP00000022632	ENSOCUP00000039591	G protein subunit alpha transducin 3.	Inositol 1,4,5-trisphosphate receptor type 3.	0.456
GNAT3	PLCB1	ENSOCUP00000022632	ENSOCUP00000036536	G protein subunit alpha transducin 3.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.860
GNAT3	PLCB2	ENSOCUP00000022632	ENSOCUP00000005658	G protein subunit alpha transducin 3.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.979
GNB3	GNAO1	ENSOCUP00000011129	ENSOCUP00000040227	G protein subunit beta 3.	G protein subunit alpha o1.	0.972
GNB3	GNAT3	ENSOCUP00000011129	ENSOCUP00000022632	G protein subunit beta 3.	G protein subunit alpha transducin 3.	0.971
GNB3	GNB5	ENSOCUP00000011129	ENSOCUP00000010220	G protein subunit beta 3.	Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...]	0.874
GNB3	GNG4	ENSOCUP00000011129	ENSOCUP00000005907	G protein subunit beta 3.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.995
GNB3	PIK3CG	ENSOCUP00000011129	ENSOCUP00000010960	G protein subunit beta 3.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.862
GNB3	PLCB1	ENSOCUP00000011129	ENSOCUP00000036536	G protein subunit beta 3.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.881

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