STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HINT1Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] (126 aa)    
Predicted Functional Partners:
RGS20
RGS domain-containing protein.
   
  
 0.657
TAF1B
TATA-box binding protein associated factor, RNA polymerase I subunit B.
    
 0.641
CTSA
Carboxypeptidase; Belongs to the peptidase S10 family.
      
 0.612
EST1_RABIT
Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family.
   
  
 0.564
TAF1A
TATA-box binding protein associated factor, RNA polymerase I subunit A.
    
 0.552
G1TLJ2_RABIT
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.552
LOC100348029
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.552
G1U2X0_RABIT
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.552
TBPL2
TATA-box binding protein like 2.
    
 0.545
TBP
TATA-box binding protein.
    
 0.545
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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