node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTSA | EST1_RABIT | ENSOCUP00000046868 | ENSOCUP00000040102 | Carboxypeptidase; Belongs to the peptidase S10 family. | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | 0.468 |
CTSA | HINT1 | ENSOCUP00000046868 | ENSOCUP00000005709 | Carboxypeptidase; Belongs to the peptidase S10 family. | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | 0.612 |
EST1_RABIT | CTSA | ENSOCUP00000040102 | ENSOCUP00000046868 | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.468 |
EST1_RABIT | HINT1 | ENSOCUP00000040102 | ENSOCUP00000005709 | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | 0.564 |
G1TLJ2_RABIT | G1U2X0_RABIT | ENSOCUP00000017843 | ENSOCUP00000023724 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |
G1TLJ2_RABIT | HINT1 | ENSOCUP00000017843 | ENSOCUP00000005709 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | 0.552 |
G1TLJ2_RABIT | LOC100348029 | ENSOCUP00000017843 | ENSOCUP00000018584 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |
G1U2X0_RABIT | G1TLJ2_RABIT | ENSOCUP00000023724 | ENSOCUP00000017843 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |
G1U2X0_RABIT | HINT1 | ENSOCUP00000023724 | ENSOCUP00000005709 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | 0.552 |
G1U2X0_RABIT | LOC100348029 | ENSOCUP00000023724 | ENSOCUP00000018584 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |
HINT1 | CTSA | ENSOCUP00000005709 | ENSOCUP00000046868 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | Carboxypeptidase; Belongs to the peptidase S10 family. | 0.612 |
HINT1 | EST1_RABIT | ENSOCUP00000005709 | ENSOCUP00000040102 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. | 0.564 |
HINT1 | G1TLJ2_RABIT | ENSOCUP00000005709 | ENSOCUP00000017843 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.552 |
HINT1 | G1U2X0_RABIT | ENSOCUP00000005709 | ENSOCUP00000023724 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.552 |
HINT1 | LOC100348029 | ENSOCUP00000005709 | ENSOCUP00000018584 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.552 |
HINT1 | RGS20 | ENSOCUP00000005709 | ENSOCUP00000038814 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | RGS domain-containing protein. | 0.657 |
HINT1 | TAF1A | ENSOCUP00000005709 | ENSOCUP00000000527 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | TATA-box binding protein associated factor, RNA polymerase I subunit A. | 0.552 |
HINT1 | TAF1B | ENSOCUP00000005709 | ENSOCUP00000040708 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | TATA-box binding protein associated factor, RNA polymerase I subunit B. | 0.641 |
HINT1 | TBP | ENSOCUP00000005709 | ENSOCUP00000021552 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | TATA-box binding protein. | 0.545 |
HINT1 | TBPL2 | ENSOCUP00000005709 | ENSOCUP00000012671 | Histidine triad nucleotide-binding protein 1; Functions as enzyme, and as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity). Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'mon [...] | TATA-box binding protein like 2. | 0.545 |