node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | DCN | ENSOCUP00000048202 | ENSOCUP00000006027 | CD44 molecule (Indian blood group). | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.529 |
CD44 | ENSOCUP00000040886 | ENSOCUP00000048202 | ENSOCUP00000040886 | CD44 molecule (Indian blood group). | Uncharacterized protein. | 0.527 |
CD44 | GAPDH | ENSOCUP00000048202 | ENSOCUP00000044112 | CD44 molecule (Indian blood group). | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.848 |
CD44 | LOC103345451 | ENSOCUP00000048202 | ENSOCUP00000031740 | CD44 molecule (Indian blood group). | TGFb_propeptide domain-containing protein. | 0.617 |
CD44 | MMP2 | ENSOCUP00000048202 | ENSOCUP00000034116 | CD44 molecule (Indian blood group). | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] | 0.815 |
CD44 | PXDN | ENSOCUP00000048202 | ENSOCUP00000022906 | CD44 molecule (Indian blood group). | Peroxidasin. | 0.778 |
CD44 | SPP1 | ENSOCUP00000048202 | ENSOCUP00000021885 | CD44 molecule (Indian blood group). | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.999 |
CD44 | TIMP1 | ENSOCUP00000048202 | ENSOCUP00000009228 | CD44 molecule (Indian blood group). | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.689 |
CD44 | TIMP3 | ENSOCUP00000048202 | ENSOCUP00000007183 | CD44 molecule (Indian blood group). | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). | 0.452 |
DCN | CD44 | ENSOCUP00000006027 | ENSOCUP00000048202 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | CD44 molecule (Indian blood group). | 0.529 |
DCN | ENSOCUP00000040886 | ENSOCUP00000006027 | ENSOCUP00000040886 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Uncharacterized protein. | 0.957 |
DCN | GAPDH | ENSOCUP00000006027 | ENSOCUP00000044112 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.717 |
DCN | LOC103345451 | ENSOCUP00000006027 | ENSOCUP00000031740 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | TGFb_propeptide domain-containing protein. | 0.984 |
DCN | MMP2 | ENSOCUP00000006027 | ENSOCUP00000034116 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] | 0.794 |
DCN | SPP1 | ENSOCUP00000006027 | ENSOCUP00000021885 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.811 |
DCN | TIMP1 | ENSOCUP00000006027 | ENSOCUP00000009228 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.499 |
DCN | TIMP3 | ENSOCUP00000006027 | ENSOCUP00000007183 | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). | 0.612 |
ENSOCUP00000040886 | CD44 | ENSOCUP00000040886 | ENSOCUP00000048202 | Uncharacterized protein. | CD44 molecule (Indian blood group). | 0.527 |
ENSOCUP00000040886 | DCN | ENSOCUP00000040886 | ENSOCUP00000006027 | Uncharacterized protein. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.957 |
ENSOCUP00000040886 | GAPDH | ENSOCUP00000040886 | ENSOCUP00000044112 | Uncharacterized protein. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] | 0.740 |