IL22RA1 protein (Oryctolagus cuniculus) - STRING interaction network

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Score

IL22RA1

Interleukin 22 receptor subunit alpha 1. (679 aa)

Predicted Functional Partners:

IL22

0.999

IL10RB

0.992

IL20RB

0.964

JAK1

0.958

IL20

0.923

JAK2

0.848

IL19

0.813

IL10

0.808

STAT3

0.805

IL10RA

0.795

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL10	IL10RA	ENSOCUP00000019534	ENSOCUP00000027490	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.999
IL10	IL10RB	ENSOCUP00000019534	ENSOCUP00000001025	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.996
IL10	IL19	ENSOCUP00000019534	ENSOCUP00000012271	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 19.	0.669
IL10	IL22	ENSOCUP00000019534	ENSOCUP00000001423	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.905
IL10	IL22RA1	ENSOCUP00000019534	ENSOCUP00000005829	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.808
IL10	JAK1	ENSOCUP00000019534	ENSOCUP00000005398	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.856
IL10	JAK2	ENSOCUP00000019534	ENSOCUP00000014491	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.758
IL10	STAT3	ENSOCUP00000019534	ENSOCUP00000009494	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Signal transducer and activator of transcription.	0.911
IL10RA	IL10	ENSOCUP00000027490	ENSOCUP00000019534	Interleukin 10 receptor subunit alpha.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.999
IL10RA	IL10RB	ENSOCUP00000027490	ENSOCUP00000001025	Interleukin 10 receptor subunit alpha.	Interleukin 10 receptor subunit beta.	0.996
IL10RA	IL19	ENSOCUP00000027490	ENSOCUP00000012271	Interleukin 10 receptor subunit alpha.	Interleukin 19.	0.762
IL10RA	IL20	ENSOCUP00000027490	ENSOCUP00000012278	Interleukin 10 receptor subunit alpha.	Interleukin 20.	0.655
IL10RA	IL20RB	ENSOCUP00000027490	ENSOCUP00000032758	Interleukin 10 receptor subunit alpha.	Interleukin 20 receptor subunit beta.	0.569
IL10RA	IL22	ENSOCUP00000027490	ENSOCUP00000001423	Interleukin 10 receptor subunit alpha.	Interleukin 22.	0.831
IL10RA	IL22RA1	ENSOCUP00000027490	ENSOCUP00000005829	Interleukin 10 receptor subunit alpha.	Interleukin 22 receptor subunit alpha 1.	0.795
IL10RA	JAK1	ENSOCUP00000027490	ENSOCUP00000005398	Interleukin 10 receptor subunit alpha.	Tyrosine-protein kinase.	0.998
IL10RA	JAK2	ENSOCUP00000027490	ENSOCUP00000014491	Interleukin 10 receptor subunit alpha.	Tyrosine-protein kinase.	0.920
IL10RA	STAT3	ENSOCUP00000027490	ENSOCUP00000009494	Interleukin 10 receptor subunit alpha.	Signal transducer and activator of transcription.	0.897
IL10RB	IL10	ENSOCUP00000001025	ENSOCUP00000019534	Interleukin 10 receptor subunit beta.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.996
IL10RB	IL10RA	ENSOCUP00000001025	ENSOCUP00000027490	Interleukin 10 receptor subunit beta.	Interleukin 10 receptor subunit alpha.	0.996