node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE | AGT | ENSOCUP00000022251 | ENSOCUP00000000417 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensinogen; Belongs to the serpin family. | 0.979 |
ACE | AQP2 | ENSOCUP00000022251 | ENSOCUP00000047709 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.501 |
ACE | AQP4 | ENSOCUP00000022251 | ENSOCUP00000007625 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.433 |
ACE | SLC14A2 | ENSOCUP00000022251 | ENSOCUP00000005837 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. | 0.517 |
AGT | ACE | ENSOCUP00000000417 | ENSOCUP00000022251 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.979 |
AGT | AQP2 | ENSOCUP00000000417 | ENSOCUP00000047709 | Angiotensinogen; Belongs to the serpin family. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.442 |
AGT | AQP4 | ENSOCUP00000000417 | ENSOCUP00000007625 | Angiotensinogen; Belongs to the serpin family. | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.627 |
AGT | SLC14A2 | ENSOCUP00000000417 | ENSOCUP00000005837 | Angiotensinogen; Belongs to the serpin family. | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. | 0.526 |
AQP2 | ACE | ENSOCUP00000047709 | ENSOCUP00000022251 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.501 |
AQP2 | AGT | ENSOCUP00000047709 | ENSOCUP00000000417 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Angiotensinogen; Belongs to the serpin family. | 0.442 |
AQP2 | AQP4 | ENSOCUP00000047709 | ENSOCUP00000007625 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.520 |
AQP2 | SLC12A3 | ENSOCUP00000047709 | ENSOCUP00000034255 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Uncharacterized protein. | 0.704 |
AQP2 | SLC14A2 | ENSOCUP00000047709 | ENSOCUP00000005837 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. | 0.562 |
AQP4 | ACE | ENSOCUP00000007625 | ENSOCUP00000022251 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.433 |
AQP4 | AGT | ENSOCUP00000007625 | ENSOCUP00000000417 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Angiotensinogen; Belongs to the serpin family. | 0.627 |
AQP4 | AQP2 | ENSOCUP00000007625 | ENSOCUP00000047709 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.520 |
AQP4 | SLC14A2 | ENSOCUP00000007625 | ENSOCUP00000005837 | Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. | 0.679 |
CCDC172 | LRMDA | ENSOCUP00000011664 | ENSOCUP00000034911 | Coiled-coil domain containing 172. | Leucine rich melanocyte differentiation associated. | 0.841 |
CCDC172 | SLC14A2 | ENSOCUP00000011664 | ENSOCUP00000005837 | Coiled-coil domain containing 172. | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. | 0.708 |
CCDC172 | THNSL2 | ENSOCUP00000011664 | ENSOCUP00000030749 | Coiled-coil domain containing 172. | Threonine synthase like 2. | 0.801 |