Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SLC14A1Urea transporter; Belongs to the urea transporter family. (384 aa)    
Predicted Functional Partners:
AQP2
Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.763
ATP6V0D2
V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.
    
   0.691
ATP6V0D1
ATPase H+ transporting V0 subunit d1.
    
   0.691
AQP3
Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.689
SLC12A1
Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system. Belongs to the SLC12A transporter family.
   
  
 0.605
ATP6V1F
V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
    
   0.594
WDR82
WD repeat domain 82.
      
 0.560
GSK3B
Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.
      
 0.560
PPARGC1A
PPARG coactivator 1 alpha.
      
 0.560
RBBP5
RB binding protein 5, histone lysine methyltransferase complex subunit.
      
 0.560
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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