HERC2 protein (Oryctolagus cuniculus) - STRING interaction network

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HERC2

HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4806 aa)

Predicted Functional Partners:

RNF8

0.865

DOCK10

0.773

USP35

0.772

USP32

0.697

USP20

0.697

UBE3A

0.691

BRCA1

0.681

MAPK6

0.675

MYT1L

0.654

RNF168

0.644

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	HERC2	ENSOCUP00000003366	ENSOCUP00000005856	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.681
BRCA1	RNF168	ENSOCUP00000003366	ENSOCUP00000010601	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.948
BRCA1	RNF8	ENSOCUP00000003366	ENSOCUP00000036851	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ring finger protein 8.	0.934
DOCK10	HERC2	ENSOCUP00000030679	ENSOCUP00000005856	Dedicator of cytokinesis 10; Belongs to the DOCK family.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.773
HERC2	BRCA1	ENSOCUP00000005856	ENSOCUP00000003366	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.681
HERC2	DOCK10	ENSOCUP00000005856	ENSOCUP00000030679	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Dedicator of cytokinesis 10; Belongs to the DOCK family.	0.773
HERC2	MAPK6	ENSOCUP00000005856	ENSOCUP00000010490	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Mitogen-activated protein kinase 6.	0.675
HERC2	MYT1L	ENSOCUP00000005856	ENSOCUP00000041999	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Myelin transcription factor 1 like.	0.654
HERC2	RNF168	ENSOCUP00000005856	ENSOCUP00000010601	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	0.644
HERC2	RNF8	ENSOCUP00000005856	ENSOCUP00000036851	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ring finger protein 8.	0.865
HERC2	UBE3A	ENSOCUP00000005856	ENSOCUP00000017548	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.691
HERC2	USP20	ENSOCUP00000005856	ENSOCUP00000047262	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.697
HERC2	USP32	ENSOCUP00000005856	ENSOCUP00000008115	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.697
HERC2	USP35	ENSOCUP00000005856	ENSOCUP00000042163	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.772
MAPK6	HERC2	ENSOCUP00000010490	ENSOCUP00000005856	Mitogen-activated protein kinase 6.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.675
MAPK6	UBE3A	ENSOCUP00000010490	ENSOCUP00000017548	Mitogen-activated protein kinase 6.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.524
MYT1L	HERC2	ENSOCUP00000041999	ENSOCUP00000005856	Myelin transcription factor 1 like.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.654
RNF168	BRCA1	ENSOCUP00000010601	ENSOCUP00000003366	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.948
RNF168	HERC2	ENSOCUP00000010601	ENSOCUP00000005856	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.644
RNF168	RNF8	ENSOCUP00000010601	ENSOCUP00000036851	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]	Ring finger protein 8.	0.990