HERC2 protein (Oryctolagus cuniculus) - STRING interaction network

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Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	HERC2	ENSOCUP00000003366	ENSOCUP00000005856	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.903
BRCA1	RNF8	ENSOCUP00000003366	ENSOCUP00000036851	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ring finger protein 8.	0.906
CEP170	HERC2	ENSOCUP00000000155	ENSOCUP00000005856	Centrosomal protein 170.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.817
FBXL5	HERC2	ENSOCUP00000038130	ENSOCUP00000005856	F-box and leucine rich repeat protein 5.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.833
FBXL5	NCOA4	ENSOCUP00000038130	ENSOCUP00000044898	F-box and leucine rich repeat protein 5.	Uncharacterized protein.	0.440
G1U8Z6_RABIT	HERC2	ENSOCUP00000025914	ENSOCUP00000005856	ARA70 domain-containing protein.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.829
HERC2	BRCA1	ENSOCUP00000005856	ENSOCUP00000003366	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.903
HERC2	CEP170	ENSOCUP00000005856	ENSOCUP00000000155	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Centrosomal protein 170.	0.817
HERC2	FBXL5	ENSOCUP00000005856	ENSOCUP00000038130	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	F-box and leucine rich repeat protein 5.	0.833
HERC2	G1U8Z6_RABIT	ENSOCUP00000005856	ENSOCUP00000025914	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	ARA70 domain-containing protein.	0.829
HERC2	MAPK6	ENSOCUP00000005856	ENSOCUP00000010490	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Mitogen-activated protein kinase 6.	0.805
HERC2	NCOA4	ENSOCUP00000005856	ENSOCUP00000044898	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Uncharacterized protein.	0.846
HERC2	RNF8	ENSOCUP00000005856	ENSOCUP00000036851	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ring finger protein 8.	0.967
HERC2	UBE3A	ENSOCUP00000005856	ENSOCUP00000017548	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.899
HERC2	USP16	ENSOCUP00000005856	ENSOCUP00000031799	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.833
HERC2	USP20	ENSOCUP00000005856	ENSOCUP00000047262	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.830
MAPK6	HERC2	ENSOCUP00000010490	ENSOCUP00000005856	Mitogen-activated protein kinase 6.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.805
MAPK6	UBE3A	ENSOCUP00000010490	ENSOCUP00000017548	Mitogen-activated protein kinase 6.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.635
NCOA4	FBXL5	ENSOCUP00000044898	ENSOCUP00000038130	Uncharacterized protein.	F-box and leucine rich repeat protein 5.	0.440
NCOA4	HERC2	ENSOCUP00000044898	ENSOCUP00000005856	Uncharacterized protein.	HECT and RLD domain containing E3 ubiquitin protein ligase 2.	0.846