STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KSR1Kinase suppressor of ras 1. (851 aa)    
Predicted Functional Partners:
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]
   
 0.993
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
    
0.968
BRAP
BRCA1 associated protein.
    
 0.965
KSR2
Kinase suppressor of ras 2.
     
0.934
CD209
C-type lectin domain-containing protein.
   
 0.912
PLK3
Serine/threonine-protein kinase PLK.
    
0.863
MAP2K5
Mitogen-activated protein kinase kinase 5.
   
 0.788
CNKSR1
Connector enhancer of kinase suppressor of Ras 1.
    
 0.768
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
   
0.758
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
   
0.746
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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