IRS1 protein (Oryctolagus cuniculus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

IRS1

Insulin receptor substrate 1. (1220 aa)

Predicted Functional Partners:

GRB2

0.999

INSR

0.997

INS

0.996

PIK3R1

0.985

PTPN11

0.981

LOC100345250

0.979

JAK2

0.978

IGF1R

0.975

PIK3CA

0.974

PIK3CB

0.963

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB2	IGF1R	ENSOCUP00000042433	ENSOCUP00000012731	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.804
GRB2	INS	ENSOCUP00000042433	ENSOCUP00000020463	Growth factor receptor bound protein 2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.797
GRB2	INSR	ENSOCUP00000042433	ENSOCUP00000042281	Growth factor receptor bound protein 2.	Tyrosine-protein kinase receptor.	0.978
GRB2	IRS1	ENSOCUP00000042433	ENSOCUP00000006209	Growth factor receptor bound protein 2.	Insulin receptor substrate 1.	0.999
GRB2	JAK2	ENSOCUP00000042433	ENSOCUP00000014491	Growth factor receptor bound protein 2.	Tyrosine-protein kinase.	0.887
GRB2	LOC100345250	ENSOCUP00000042433	ENSOCUP00000012307	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.846
GRB2	PIK3CA	ENSOCUP00000042433	ENSOCUP00000026298	Growth factor receptor bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.744
GRB2	PIK3CB	ENSOCUP00000042433	ENSOCUP00000004241	Growth factor receptor bound protein 2.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.635
GRB2	PIK3R1	ENSOCUP00000042433	ENSOCUP00000004433	Growth factor receptor bound protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.981
GRB2	PTPN11	ENSOCUP00000042433	ENSOCUP00000003911	Growth factor receptor bound protein 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.999
IGF1R	GRB2	ENSOCUP00000012731	ENSOCUP00000042433	Tyrosine-protein kinase receptor.	Growth factor receptor bound protein 2.	0.804
IGF1R	INS	ENSOCUP00000012731	ENSOCUP00000020463	Tyrosine-protein kinase receptor.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.999
IGF1R	INSR	ENSOCUP00000012731	ENSOCUP00000042281	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.883
IGF1R	IRS1	ENSOCUP00000012731	ENSOCUP00000006209	Tyrosine-protein kinase receptor.	Insulin receptor substrate 1.	0.975
IGF1R	JAK2	ENSOCUP00000012731	ENSOCUP00000014491	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.513
IGF1R	LOC100345250	ENSOCUP00000012731	ENSOCUP00000012307	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.691
IGF1R	PIK3CA	ENSOCUP00000012731	ENSOCUP00000026298	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.749
IGF1R	PIK3CB	ENSOCUP00000012731	ENSOCUP00000004241	Tyrosine-protein kinase receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.468
IGF1R	PIK3R1	ENSOCUP00000012731	ENSOCUP00000004433	Tyrosine-protein kinase receptor.	Phosphoinositide-3-kinase regulatory subunit 1.	0.765
IGF1R	PTPN11	ENSOCUP00000012731	ENSOCUP00000003911	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.731