Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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KCNS3Potassium voltage-gated channel subfamily S member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. [...] (491 aa)    
Predicted Functional Partners:
KCNAB2
Potassium voltage-gated channel subfamily A regulatory beta subunit 2.
   
 0.666
KCNAB1
Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (B [...]
   
 0.666
KCNS2
Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family.
    
  0.657
KCNS1
Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family.
    
  0.629
G1U1Y5_RABIT
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
  0.628
FAU
Ubiquitin-like domain-containing protein.
   
  0.628
ENSOCUP00000046875
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
  0.628
ENSOCUP00000049185
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
   
  0.628
DALRD3
DALR anticodon binding domain containing 3.
   
  
 0.609
RPL18A
60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
   
 0.586
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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