HUWE1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

HUWE1

HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4329 aa)

Predicted Functional Partners:

MFN2

0.959

ENSOCUP00000044498

0.958

AMBRA1

0.954

MCL1

0.951

MYC

0.950

MFN1

0.916

G1SK22_RABIT

0.911

G1TZL0_RABIT

0.911

UBB

0.897

ENSOCUP00000030467

0.897

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	HUWE1	ENSOCUP00000044129	ENSOCUP00000006373	Autophagy and beclin 1 regulator 1.	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	0.954
AMBRA1	MFN2	ENSOCUP00000044129	ENSOCUP00000006893	Autophagy and beclin 1 regulator 1.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.453
ENSOCUP00000030467	ENSOCUP00000044498	ENSOCUP00000030467	ENSOCUP00000044498	Uncharacterized protein.	Ribosomal_L40e domain-containing protein.	0.971
ENSOCUP00000030467	G1SK22_RABIT	ENSOCUP00000030467	ENSOCUP00000003131	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.924
ENSOCUP00000030467	G1TZL0_RABIT	ENSOCUP00000030467	ENSOCUP00000022533	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.924
ENSOCUP00000030467	HUWE1	ENSOCUP00000030467	ENSOCUP00000006373	Uncharacterized protein.	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	0.897
ENSOCUP00000030467	MFN1	ENSOCUP00000030467	ENSOCUP00000038083	Uncharacterized protein.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.791
ENSOCUP00000030467	MFN2	ENSOCUP00000030467	ENSOCUP00000006893	Uncharacterized protein.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.791
ENSOCUP00000030467	UBB	ENSOCUP00000030467	ENSOCUP00000001111	Uncharacterized protein.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.801
ENSOCUP00000044498	ENSOCUP00000030467	ENSOCUP00000044498	ENSOCUP00000030467	Ribosomal_L40e domain-containing protein.	Uncharacterized protein.	0.971
ENSOCUP00000044498	G1SK22_RABIT	ENSOCUP00000044498	ENSOCUP00000003131	Ribosomal_L40e domain-containing protein.	Ubiquitin-like domain-containing protein.	0.999
ENSOCUP00000044498	G1TZL0_RABIT	ENSOCUP00000044498	ENSOCUP00000022533	Ribosomal_L40e domain-containing protein.	Ubiquitin-like domain-containing protein.	0.994
ENSOCUP00000044498	HUWE1	ENSOCUP00000044498	ENSOCUP00000006373	Ribosomal_L40e domain-containing protein.	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	0.958
ENSOCUP00000044498	MFN1	ENSOCUP00000044498	ENSOCUP00000038083	Ribosomal_L40e domain-containing protein.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.849
ENSOCUP00000044498	MFN2	ENSOCUP00000044498	ENSOCUP00000006893	Ribosomal_L40e domain-containing protein.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.847
ENSOCUP00000044498	UBB	ENSOCUP00000044498	ENSOCUP00000001111	Ribosomal_L40e domain-containing protein.	Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]	0.971
G1SK22_RABIT	ENSOCUP00000030467	ENSOCUP00000003131	ENSOCUP00000030467	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.924
G1SK22_RABIT	ENSOCUP00000044498	ENSOCUP00000003131	ENSOCUP00000044498	Ubiquitin-like domain-containing protein.	Ribosomal_L40e domain-containing protein.	0.999
G1SK22_RABIT	HUWE1	ENSOCUP00000003131	ENSOCUP00000006373	Ubiquitin-like domain-containing protein.	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	0.911
G1SK22_RABIT	MFN1	ENSOCUP00000003131	ENSOCUP00000038083	Ubiquitin-like domain-containing protein.	Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.770