Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | DYRK3 | ENSOCUP00000012638 | ENSOCUP00000006417 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Dual specificity tyrosine phosphorylation regulated kinase 3. | 0.554 |
| ATM | G1U940_RABIT | ENSOCUP00000012638 | ENSOCUP00000025959 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.917 |
| ATM | PLK3 | ENSOCUP00000012638 | ENSOCUP00000024465 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Serine/threonine-protein kinase PLK. | 0.515 |
| ATM | TP53 | ENSOCUP00000012638 | ENSOCUP00000000989 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.997 |
| ATM | UBE2I | ENSOCUP00000012638 | ENSOCUP00000026696 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.617 |
| CFAP36 | DYRK3 | ENSOCUP00000005944 | ENSOCUP00000006417 | Cilia and flagella associated protein 36. | Dual specificity tyrosine phosphorylation regulated kinase 3. | 0.519 |
| DCAF7 | DYRK3 | ENSOCUP00000013632 | ENSOCUP00000006417 | DDB1 and CUL4 associated factor 7. | Dual specificity tyrosine phosphorylation regulated kinase 3. | 0.728 |
| DCAF7 | WDR73 | ENSOCUP00000013632 | ENSOCUP00000015345 | DDB1 and CUL4 associated factor 7. | WD repeat domain 73. | 0.547 |
| DYRK3 | ATM | ENSOCUP00000006417 | ENSOCUP00000012638 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.554 |
| DYRK3 | CFAP36 | ENSOCUP00000006417 | ENSOCUP00000005944 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Cilia and flagella associated protein 36. | 0.519 |
| DYRK3 | DCAF7 | ENSOCUP00000006417 | ENSOCUP00000013632 | Dual specificity tyrosine phosphorylation regulated kinase 3. | DDB1 and CUL4 associated factor 7. | 0.728 |
| DYRK3 | EPB42 | ENSOCUP00000006417 | ENSOCUP00000015000 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Erythrocyte membrane protein band 4.2. | 0.506 |
| DYRK3 | G1U940_RABIT | ENSOCUP00000006417 | ENSOCUP00000025959 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.542 |
| DYRK3 | PLK3 | ENSOCUP00000006417 | ENSOCUP00000024465 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Serine/threonine-protein kinase PLK. | 0.466 |
| DYRK3 | SLC13A2 | ENSOCUP00000006417 | ENSOCUP00000011839 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate. | 0.528 |
| DYRK3 | TP53 | ENSOCUP00000006417 | ENSOCUP00000000989 | Dual specificity tyrosine phosphorylation regulated kinase 3. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.542 |
| DYRK3 | UBE2I | ENSOCUP00000006417 | ENSOCUP00000026696 | Dual specificity tyrosine phosphorylation regulated kinase 3. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.494 |
| DYRK3 | WDR73 | ENSOCUP00000006417 | ENSOCUP00000015345 | Dual specificity tyrosine phosphorylation regulated kinase 3. | WD repeat domain 73. | 0.554 |
| EPB42 | DYRK3 | ENSOCUP00000015000 | ENSOCUP00000006417 | Erythrocyte membrane protein band 4.2. | Dual specificity tyrosine phosphorylation regulated kinase 3. | 0.506 |
| G1U940_RABIT | ATM | ENSOCUP00000025959 | ENSOCUP00000012638 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.917 |
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