Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SOD3Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen; Belongs to the Cu-Zn superoxide dismutase family. (393 aa)    
Predicted Functional Partners:
CCS
Copper chaperone for superoxide dismutase.
   
 0.951
PARK7
Parkinsonism associated deglycase.
  
 0.912
CAT
Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.
  
 0.898
HSPA5
Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.
   
 0.844
ATOX1
Antioxidant 1 copper chaperone.
   
 0.826
PSMD4
Proteasome 26S subunit, non-ATPase, 4 (Predicted).
   
 0.817
PSMB1
Proteasome subunit beta 1.
   
 
 0.811
PSMB4
Proteasome subunit beta; Belongs to the peptidase T1B family.
   
 
  0.808
PSMB3
Proteasome subunit beta.
   
 
 0.806
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.799
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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