Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LMNB1Lamin B1; Belongs to the intermediate filament family. (609 aa)    
Predicted Functional Partners:
LMNA
Lamin A/C; Belongs to the intermediate filament family.
   
 0.988
SUN2
Sad1 and UNC84 domain containing 2.
    
 0.957
EMD
Emerin (Predicted).
    
 0.955
CASP6
Caspase 6; Belongs to the phospholipase A2 family.
   
 0.918
BANF1
Uncharacterized protein.
    
 0.911
TMPO
Thymopoietin.
   
 0.908
SYNE2
KASH domain-containing protein.
   
 0.895
SYNE1
Spectrin repeat containing nuclear envelope protein 1.
   
 0.883
NUP153
Nucleoporin 153.
    
 
 0.868
CASP3
Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.
   
 0.867
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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