node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | CASP4 | ENSOCUP00000010200 | ENSOCUP00000006490 | Apoptotic peptidase activating factor 1. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.869 |
APAF1 | CASP8 | ENSOCUP00000010200 | ENSOCUP00000049942 | Apoptotic peptidase activating factor 1. | DED domain-containing protein. | 0.977 |
APAF1 | CYCS | ENSOCUP00000010200 | ENSOCUP00000019281 | Apoptotic peptidase activating factor 1. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.999 |
APPL1 | APPL2 | ENSOCUP00000005905 | ENSOCUP00000034170 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | 0.990 |
APPL1 | CASP4 | ENSOCUP00000005905 | ENSOCUP00000006490 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.716 |
APPL1 | CASP8 | ENSOCUP00000005905 | ENSOCUP00000049942 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | DED domain-containing protein. | 0.716 |
APPL2 | APPL1 | ENSOCUP00000034170 | ENSOCUP00000005905 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | 0.990 |
APPL2 | CASP4 | ENSOCUP00000034170 | ENSOCUP00000006490 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.716 |
APPL2 | CASP8 | ENSOCUP00000034170 | ENSOCUP00000049942 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | DED domain-containing protein. | 0.716 |
ATF6 | CASP4 | ENSOCUP00000035397 | ENSOCUP00000006490 | Activating transcription factor 6. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.684 |
ATF6 | CASP8 | ENSOCUP00000035397 | ENSOCUP00000049942 | Activating transcription factor 6. | DED domain-containing protein. | 0.569 |
ATF6 | CYCS | ENSOCUP00000035397 | ENSOCUP00000019281 | Activating transcription factor 6. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.668 |
ATF6 | DDIT3 | ENSOCUP00000035397 | ENSOCUP00000016579 | Activating transcription factor 6. | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] | 0.994 |
ATF6 | IL1B | ENSOCUP00000035397 | ENSOCUP00000021869 | Activating transcription factor 6. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.542 |
CASP4 | APAF1 | ENSOCUP00000006490 | ENSOCUP00000010200 | Uncharacterized protein; Belongs to the peptidase C14A family. | Apoptotic peptidase activating factor 1. | 0.869 |
CASP4 | APPL1 | ENSOCUP00000006490 | ENSOCUP00000005905 | Uncharacterized protein; Belongs to the peptidase C14A family. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | 0.716 |
CASP4 | APPL2 | ENSOCUP00000006490 | ENSOCUP00000034170 | Uncharacterized protein; Belongs to the peptidase C14A family. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. | 0.716 |
CASP4 | ATF6 | ENSOCUP00000006490 | ENSOCUP00000035397 | Uncharacterized protein; Belongs to the peptidase C14A family. | Activating transcription factor 6. | 0.684 |
CASP4 | CASP8 | ENSOCUP00000006490 | ENSOCUP00000049942 | Uncharacterized protein; Belongs to the peptidase C14A family. | DED domain-containing protein. | 0.698 |
CASP4 | CYCS | ENSOCUP00000006490 | ENSOCUP00000019281 | Uncharacterized protein; Belongs to the peptidase C14A family. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.683 |