CTH protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCYL1	BHMT	ENSOCUP00000008381	ENSOCUP00000031900	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Hcy-binding domain-containing protein.	0.951
AHCYL1	CBS	ENSOCUP00000008381	ENSOCUP00000034549	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	0.933
AHCYL1	CTH	ENSOCUP00000008381	ENSOCUP00000006510	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Cystathionine gamma-lyase.	0.924
AHCYL1	MTHFR	ENSOCUP00000008381	ENSOCUP00000006304	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.655
AHCYL1	MTR	ENSOCUP00000008381	ENSOCUP00000008420	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.943
AHCYL1	SDS	ENSOCUP00000008381	ENSOCUP00000018669	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	Serine dehydratase.	0.862
BHMT	AHCYL1	ENSOCUP00000031900	ENSOCUP00000008381	Hcy-binding domain-containing protein.	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	0.951
BHMT	CBS	ENSOCUP00000031900	ENSOCUP00000034549	Hcy-binding domain-containing protein.	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	0.958
BHMT	CDO1	ENSOCUP00000031900	ENSOCUP00000000129	Hcy-binding domain-containing protein.	Cysteine dioxygenase.	0.494
BHMT	CTH	ENSOCUP00000031900	ENSOCUP00000006510	Hcy-binding domain-containing protein.	Cystathionine gamma-lyase.	0.964
BHMT	MTHFR	ENSOCUP00000031900	ENSOCUP00000006304	Hcy-binding domain-containing protein.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.961
BHMT	MTR	ENSOCUP00000031900	ENSOCUP00000008420	Hcy-binding domain-containing protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.971
BHMT	SDS	ENSOCUP00000031900	ENSOCUP00000018669	Hcy-binding domain-containing protein.	Serine dehydratase.	0.912
CBS	AHCYL1	ENSOCUP00000034549	ENSOCUP00000008381	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.	0.933
CBS	BHMT	ENSOCUP00000034549	ENSOCUP00000031900	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Hcy-binding domain-containing protein.	0.958
CBS	CDO1	ENSOCUP00000034549	ENSOCUP00000000129	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Cysteine dioxygenase.	0.914
CBS	CTH	ENSOCUP00000034549	ENSOCUP00000006510	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Cystathionine gamma-lyase.	0.999
CBS	GCLC	ENSOCUP00000034549	ENSOCUP00000044485	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Glutamate-cysteine ligase catalytic subunit.	0.889
CBS	MPST	ENSOCUP00000034549	ENSOCUP00000042910	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Uncharacterized protein.	0.927
CBS	MTHFR	ENSOCUP00000034549	ENSOCUP00000006304	Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.912